| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE48355.1 | AEE49884.1 | Halhy_0444 | Halhy_1999 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | 0.927 |
| AEE48355.1 | AEE51110.1 | Halhy_0444 | Halhy_3250 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | 0.489 |
| AEE48355.1 | AEE51361.1 | Halhy_0444 | Halhy_3506 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006098:IPR006159:IPR006099:IPR006158; KEGG: lic:LIC20209 methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; Cobalamin (vitamin B12)-binding; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-COA mutase large subunit; TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; Methylmalonyl-CoA mutase, C-terminal; IMG reference gene:2504772887; PFAM: Methylmalonyl-CoA mutase; B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylmalonyl-CoA mutase [...] | 0.478 |
| AEE48355.1 | AEE51969.1 | Halhy_0444 | Halhy_4123 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | Phenylacetic acid degradation protein paaN; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590:IPR002539:IPR011966; KEGG: rmr:Rmar_1556 phenylacetic acid degradation protein PaaN; PFAM: MaoC-like dehydratase; Aldehyde dehydrogenase; PRIAM: Aldehyde dehydrogenase (NAD(+)); SPTR: NAD-dependent aldehyde dehydrogenases; TIGRFAM: Phenylacetic acid degradation protein paaN; IMG reference gene:2504773509; PFAM: MaoC like domain; Aldehyde dehydrogenase family; TIGRFAM: phenylacetic acid degradation protein paaN. | 0.557 |
| AEE48355.1 | eno | Halhy_0444 | Halhy_4777 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.496 |
| AEE48355.1 | icmF | Halhy_0444 | Halhy_2347 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | Methylmalonyl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. | 0.500 |
| AEE48355.1 | sucC | Halhy_0444 | Halhy_5799 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.684 |
| AEE48355.1 | sucD | Halhy_0444 | Halhy_4779 | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.516 |
| AEE49884.1 | AEE48355.1 | Halhy_1999 | Halhy_0444 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 0.927 |
| AEE49884.1 | AEE51110.1 | Halhy_1999 | Halhy_3250 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | 0.667 |
| AEE49884.1 | AEE51361.1 | Halhy_1999 | Halhy_3506 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | COGs: COG1884 Methylmalonyl-CoA mutase N-terminal domain/subunit; InterPro IPR006098:IPR006159:IPR006099:IPR006158; KEGG: lic:LIC20209 methylmalonyl-CoA mutase; PFAM: Methylmalonyl-CoA mutase, alpha/beta chain, catalytic; Cobalamin (vitamin B12)-binding; PRIAM: Methylmalonyl-CoA mutase; SPTR: Methylmalonyl-COA mutase large subunit; TIGRFAM: Methylmalonyl-CoA mutase, alpha chain, catalytic; Methylmalonyl-CoA mutase, C-terminal; IMG reference gene:2504772887; PFAM: Methylmalonyl-CoA mutase; B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain; methylmalonyl-CoA mutase [...] | 0.855 |
| AEE49884.1 | AEE51969.1 | Halhy_1999 | Halhy_4123 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | Phenylacetic acid degradation protein paaN; COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR015590:IPR002539:IPR011966; KEGG: rmr:Rmar_1556 phenylacetic acid degradation protein PaaN; PFAM: MaoC-like dehydratase; Aldehyde dehydrogenase; PRIAM: Aldehyde dehydrogenase (NAD(+)); SPTR: NAD-dependent aldehyde dehydrogenases; TIGRFAM: Phenylacetic acid degradation protein paaN; IMG reference gene:2504773509; PFAM: MaoC like domain; Aldehyde dehydrogenase family; TIGRFAM: phenylacetic acid degradation protein paaN. | 0.710 |
| AEE49884.1 | eno | Halhy_1999 | Halhy_4777 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.457 |
| AEE49884.1 | sucC | Halhy_1999 | Halhy_5799 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | Succinyl-CoA ligase (ADP-forming) subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.962 |
| AEE49884.1 | sucD | Halhy_1999 | Halhy_4779 | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.850 |
| AEE50780.1 | AEE51110.1 | Halhy_2916 | Halhy_3250 | COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: mev:Metev_1525 histone deacetylase superfamily; PFAM: Histone deacetylase superfamily; SPTR: Histone deacetylase superfamily; IMG reference gene:2504772290; PFAM: Histone deacetylase domain. | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | 0.598 |
| AEE51109.1 | AEE51110.1 | Halhy_3249 | Halhy_3250 | Hypothetical protein; KEGG: sli:Slin_4331 transcriptional regulator, AraC family; SPTR: Transcriptional regulator, AraC family; IMG reference gene:2504772629. | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | 0.520 |
| AEE51110.1 | AEE48355.1 | Halhy_3250 | Halhy_0444 | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR002505; KEGG: lby:Lbys_0673 allosteric nADP-dependent malic enzyme; PFAM: Malic enzyme, NAD-binding; Malic enzyme, N-terminal; Phosphate acetyl/butaryl transferase; SPTR: Allosteric NADP-dependent malic enzyme; IMG reference gene:2504769800; PFAM: Phosphate acetyl/butaryl transferase; Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain; TIGRFAM: phosphate acetyltransferase. | 0.489 |
| AEE51110.1 | AEE49884.1 | Halhy_3250 | Halhy_1999 | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | COGs: COG0372 Citrate synthase; InterPro IPR002020; KEGG: cpi:Cpin_6916 type I citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate (Si)-synthase; IMG reference gene:2504771365; PFAM: Citrate synthase; TIGRFAM: citrate (Si)-synthase, eukaryotic; Belongs to the citrate synthase family. | 0.667 |
| AEE51110.1 | AEE50780.1 | Halhy_3250 | Halhy_2916 | COGs: COG0427 Acetyl-CoA hydrolase; InterPro IPR003702; KEGG: cts:Ctha_0304 acetyl-CoA hydrolase/transferase; PFAM: Acetyl-CoA hydrolase/transferase; SPTR: 4-hydroxybutyrate CoA transferase; IMG reference gene:2504772630; PFAM: Acetyl-CoA hydrolase/transferase N-terminal domain. | COGs: COG0123 Deacetylase including yeast histone deacetylase and acetoin utilization protein; InterPro IPR000286; KEGG: mev:Metev_1525 histone deacetylase superfamily; PFAM: Histone deacetylase superfamily; SPTR: Histone deacetylase superfamily; IMG reference gene:2504772290; PFAM: Histone deacetylase domain. | 0.598 |
