| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE48004.1 | AEE48152.1 | Halhy_0091 | Halhy_0239 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | 0.945 |
| AEE48004.1 | AEE49495.1 | Halhy_0091 | Halhy_1604 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 5'-Nucleotidase domain-containing protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504770965; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. | 0.903 |
| AEE48004.1 | AEE50577.1 | Halhy_0091 | Halhy_2709 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR004393:IPR002638; KEGG: lby:Lbys_2650 nicotinate-nucleotide pyrophosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide diphosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; IMG reference gene:2504772080; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/Mo [...] | 0.964 |
| AEE48004.1 | AEE53950.1 | Halhy_0091 | Halhy_6128 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843; KEGG: sli:Slin_4342 metallophosphoesterase; PFAM: Metallophosphoesterase; PRIAM: 5'-nucleotidase; SPTR: Metallophosphoesterase; IMG reference gene:2504775530; PFAM: Calcineurin-like phosphoesterase. | 0.903 |
| AEE48004.1 | nadD | Halhy_0091 | Halhy_3374 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.943 |
| AEE48004.1 | nadE | Halhy_0091 | Halhy_3598 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.626 |
| AEE48004.1 | nadK | Halhy_0091 | Halhy_3160 | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.426 |
| AEE48152.1 | AEE48004.1 | Halhy_0239 | Halhy_0091 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.945 |
| AEE48152.1 | AEE49495.1 | Halhy_0239 | Halhy_1604 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | 5'-Nucleotidase domain-containing protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504770965; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. | 0.927 |
| AEE48152.1 | AEE50577.1 | Halhy_0239 | Halhy_2709 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR004393:IPR002638; KEGG: lby:Lbys_2650 nicotinate-nucleotide pyrophosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide diphosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; IMG reference gene:2504772080; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/Mo [...] | 0.928 |
| AEE48152.1 | AEE53950.1 | Halhy_0239 | Halhy_6128 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843; KEGG: sli:Slin_4342 metallophosphoesterase; PFAM: Metallophosphoesterase; PRIAM: 5'-nucleotidase; SPTR: Metallophosphoesterase; IMG reference gene:2504775530; PFAM: Calcineurin-like phosphoesterase. | 0.906 |
| AEE48152.1 | AEE54135.1 | Halhy_0239 | Halhy_6316 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | NAD(P)(+) transhydrogenase (AB-specific); COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; InterPro IPR007886:IPR007698; KEGG: rru:Rru_A2183 NAD(P)(+) transhydrogenase (AB-specific); PFAM: Alanine dehydrogenase/PNT, C-terminal; Alanine dehydrogenase/PNT, N-terminal; PRIAM: NAD(P)(+) transhydrogenase (AB-specific); SPTR: NAD(P) transhydrogenase, alpha subunit part 1; IMG reference gene:2504775724; PFAM: Alanine dehydrogenase/PNT, C-terminal domain; Alanine dehydrogenase/PNT, N-terminal domain; TIGRFAM: NAD(P) transhydrogenase, alpha subunit. | 0.900 |
| AEE48152.1 | AEE54136.1 | Halhy_0239 | Halhy_6317 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | COGs: COG3288 NAD/NADP transhydrogenase alpha subunit; KEGG: cpi:Cpin_6490 pyridine nucleotide transhydrogenase subunit alpha; SPTR: Pyridine nucleotide transhydrogenase subunit alpha; IMG reference gene:2504775725. | 0.900 |
| AEE48152.1 | cobB | Halhy_0239 | Halhy_6407 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; HAMAP: NAD-dependent deacetylase; InterPro IPR003000; KEGG: zpr:ZPR_2106 NAD-dependent histone deacetylase; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; SPTR: Putative uncharacterized protein; IMG reference gene:2504775815; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily. | 0.992 |
| AEE48152.1 | nadD | Halhy_0239 | Halhy_3374 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.928 |
| AEE48152.1 | nadE | Halhy_0239 | Halhy_3598 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.951 |
| AEE48152.1 | nadK | Halhy_0239 | Halhy_3160 | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.939 |
| AEE49495.1 | AEE48004.1 | Halhy_1604 | Halhy_0091 | 5'-Nucleotidase domain-containing protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504770965; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. | Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. | 0.903 |
| AEE49495.1 | AEE48152.1 | Halhy_1604 | Halhy_0239 | 5'-Nucleotidase domain-containing protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504770965; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. | Cytidyltransferase-related domain protein; COGs: COG3172 ATPase/kinase involved in NAD metabolism; KEGG: gym:GYMC10_6274 cytidyltransferase-related domain protein; SPTR: Cytidyltransferase-related domain protein; IMG reference gene:2504769591; TIGRFAM: nicotinamide-nucleotide adenylyltransferase, NadR type; cytidyltransferase-related domain. | 0.927 |
| AEE49495.1 | AEE50577.1 | Halhy_1604 | Halhy_2709 | 5'-Nucleotidase domain-containing protein; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase, C-terminal; Metallophosphoesterase; SPTR: Metallophosphoesterase; IMG reference gene:2504770965; PFAM: Calcineurin-like phosphoesterase; 5'-nucleotidase, C-terminal domain; Belongs to the 5'-nucleotidase family. | COGs: COG0157 Nicotinate-nucleotide pyrophosphorylase; InterPro IPR004393:IPR002638; KEGG: lby:Lbys_2650 nicotinate-nucleotide pyrophosphorylase (carboxylating); PFAM: Quinolinate phosphoribosyl transferase; PRIAM: Nicotinate-nucleotide diphosphorylase (carboxylating); SPTR: Nicotinate-nucleotide diphosphorylase; TIGRFAM: Nicotinate-nucleotide pyrophosphorylase; IMG reference gene:2504772080; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/Mo [...] | 0.900 |