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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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AEE51234.1DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)    
Predicted Functional Partners:
AEE49355.1
COGs: COG0587 DNA polymerase III alpha subunit; InterProIPR004013:IPR011708:IPR004365:IPR003141:IPR 004805; KEGG: chu:CHU_0094 DNA polymerase III, alpha subunit; PFAM: Bacterial DNA polymerase III, alpha subunit; PHP, C-terminal; Nucleic acid binding, OB-fold, tRNA/helicase-type; PRIAM: DNA-directed DNA polymerase; SMART: Polymerase/histidinol phosphatase, N-terminal; SPTR: DNA polymerase III, alpha subunit; TIGRFAM: DNA polymerase III, alpha subunit; IMG reference gene:2504770822; PFAM: PHP domain; Bacterial DNA polymerase III alpha subunit; OB-fold nucleic acid binding domain; TIGRFA [...]
  
 
 0.992
AEE48208.1
COGs: COG1466 DNA polymerase III delta subunit; InterPro IPR010372:IPR005790; KEGG: cpi:Cpin_6524 DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta; SPTR: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; IMG reference gene:2504769651; PFAM: DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit.
 
 
 0.990
AEE51037.1
COGs: COG2812 DNA polymerase III gamma/tau subunits; KEGG: cpi:Cpin_0875 DNA polymerase III gamma/tau subunits-like protein; SPTR: DNA polymerase III gamma/tau subunit; IMG reference gene:2504772556.
 
 
 0.988
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
 0.987
dnaX
DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 0.985
AEE53940.1
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006054:IPR013520:IPR000305:IPR006055; KEGG: gfo:GFO_0663 exonuclease family protein; PFAM: Exonuclease, RNase T/DNA polymerase III; Excinuclease ABC, C subunit, N-terminal; PRIAM: DNA-directed DNA polymerase; SMART: Exonuclease; Excinuclease ABC, C subunit, N-terminal; SPTR: DNA polymerase III, epsilon subunit; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2504775520; PFAM: Exonuclease; GIY-YIG catalytic domain; TIGRFAM: exonuclease, DNA polymerase III, epsilon subunit family.
   
 0.964
AEE53171.1
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006054:IPR013520:IPR006055; KEGG: lby:Lbys_2788 exonuclease RNase T and DNA polymerase III; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease; SPTR: Exonuclease RNase T and DNA polymerase III; TIGRFAM: DNA polymerase III, epsilon subunit; IMG reference gene:2504774744; PFAM: Exonuclease.
   
 0.956
AEE48087.1
COGs: COG0847 DNA polymerase III epsilon subunit and related 3'-5' exonuclease; InterPro IPR006055:IPR013520; KEGG: ppn:Palpr_3000 exonuclease RNAse t and DNA polymerase III; PFAM: Exonuclease, RNase T/DNA polymerase III; SMART: Exonuclease; SPTR: Exonuclease RNase T and DNA polymerase III; IMG reference gene:2504769526; PFAM: Exonuclease.
   
 0.950
dnaA
Chromosomal replication initiator protein dnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
 
 0.936
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.930
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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