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[Homology]
Score
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)    
Predicted Functional Partners:
hisB
COGs: COG0131 Imidazoleglycerol-phosphate dehydratase; HAMAP: Imidazoleglycerol-phosphate dehydratase; InterPro IPR005954:IPR006543:IPR013954:IPR000807; KEGG: cpi:Cpin_1820 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; PFAM: Imidazoleglycerol-phosphate dehydratase; Polynucleotide kinase 3 phosphatase, central region; PRIAM: Histidinol-phosphatase; SPTR: Histidinol-phosphatase; TIGRFAM: Histidinol-phosphatase; Histidinol-phosphate phosphatase; IMG reference gene:2504772801; PFAM: Imidazoleglycerol-phosphate dehydratase; TIGRFAM: HAD-superfamily hydrolase, subfamily II [...]
 
 0.999
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; HAMAP: Histidinol-phosphate aminotransferase; InterPro IPR005861:IPR004839; KEGG: phe:Phep_3193 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol phosphate aminotransferase apoenzyme; TIGRFAM: Histidinol-phosphate aminotransferase; IMG reference gene:2504772800; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransf [...]
  
 0.998
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
 0.997
hisI
COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504773196; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.996
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
 
  
 0.992
hisH
Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
  
 0.990
hisA
COGs: COG0106 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase; HAMAP:1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; InterPro IPR006063:IPR006062; KEGG: lby:Lbys_2915 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: Histidine biosynthesis; PRIAM:1-(5-phosphoribosyl)-5-((5-phosphoribosylamin o)methylideneamino)imidazole-4-carboxamideisomerase; SPTR: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; TIGRFAM: Phosphoribosylformimino-5-aminoimidaz [...]
 
  
 0.988
AEE50844.1
COGs: COG2986 Histidine ammonia-lyase; InterPro IPR001106:IPR005921; KEGG: fjo:Fjoh_2576 histidine ammonia-lyase; PFAM: Phenylalanine/histidine ammonia-lyase; PRIAM: Histidine ammonia-lyase; SPTR: Histidine ammonia-lyase; TIGRFAM: Histidine ammonia-lyase; IMG reference gene:2504772354; PFAM: Phenylalanine and histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase.
    
 0.931
AEE50455.1
Methyltransferase; COGs: COG4301 conserved hypothetical protein; InterPro IPR017804:IPR019257; KEGG: syp:SYNPCC7002_G0154 hypothetical protein; PFAM: Protein of unknown function DUF2260; SPTR: Putative uncharacterized protein; TIGRFAM: Methyltransferase-like; IMG reference gene:2504771956; PFAM: Uncharacterized conserved protein (DUF2260); TIGRFAM: probable methyltransferase.
     
  0.900
AEE51058.1
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR006311:IPR004839; KEGG: fbc:FB2170_12386 histidinol-phosphate aminotransferase; PFAM: Aminotransferase, class I/II; PRIAM: Histidinol-phosphate transaminase; SPTR: Histidinol-phosphate aminotransferase; IMG reference gene:2504772577; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase.
  
 0.843
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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