Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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AEE51298.1DNA mismatch repair protein MutS domain protein; COGs: COG0249 Mismatch repair ATPase (MutS family); InterPro IPR000432; KEGG: sli:Slin_5542 DNA mismatch repair protein MutS domain protein; PFAM: DNA mismatch repair protein MutS, C-terminal; SMART: DNA mismatch repair protein MutS, C-terminal; SPTR: DNA mismatch repair protein MutS; IMG reference gene:2504772823; PFAM: MutS domain V. (597 aa)    
Predicted Functional Partners:
mutL
DNA mismatch repair protein mutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
 
 0.961
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.899
AEE51234.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.808
recA
Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 0.601
AEE51299.1
Helix-turn-helix domain protein; InterPro IPR001387; KEGG: dfe:Dfer_2636 transcriptional regulator, XRE family; PFAM: Helix-turn-helix type 3; SMART: Helix-turn-helix type 3; SPTR: Putative uncharacterized protein; IMG reference gene:2504772824; PFAM: Helix-turn-helix.
       0.563
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 0.537
AEE50663.1
Helicase domain-containing protein; COGs: COG0513 Superfamily II DNA and RNA helicase; InterPro IPR014001:IPR001650:IPR000330; KEGG: pph:Ppha_1422 helicase domain protein; PFAM: DNA/RNA helicase, C-terminal; SNF2-related; SMART: DNA/RNA helicase, C-terminal; DEAD-like helicase, N-terminal; SPTR: Helicase-like; IMG reference gene:2504772166; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
  
 
 0.525
mutS2
MutS2 protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
 
  
 0.483
AEE53650.1
Transcriptional repressor, CopY family; COGs: COG3682 transcriptional regulator protein; InterPro IPR005650; KEGG: phe:Phep_0214 penicillinase repressor; PFAM: Penicillinase repressor; SPTR: Penicillinase repressor; IMG reference gene:2504775225; PFAM: Penicillinase repressor.
  
     0.481
AEE48172.1
ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterPro IPR014001:IPR001650:IPR011545:IPR018329; KEGG: phe:Phep_1902 ATP-dependent DNA helicase, RecQ family; PFAM: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; DNA/RNA helicase, C-terminal; SMART: DEAD-like helicase, N-terminal; DNA/RNA helicase, C-terminal; SPTR: ATP-dependent DNA helicase, RecQ family; TIGRFAM: DNA helicase, ATP-dependent, RecQ type, N-terminal; IMG reference gene:2504769612; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; TIGRFAM: ATP-dependent DNA helicase [...]
  
 0.466
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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