Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEE51437.1COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. (259 aa)    
Predicted Functional Partners:
AEE52545.1
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
  
 0.977
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.923
AEE52100.1
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase.
  
 
 0.916
AEE53708.1
uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase (Uroporphyrinogen III methylase); TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504775283; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
  
 
 0.916
AEE52546.1
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
     
  0.900
AEE51439.1
InterPro IPR011467; KEGG: sli:Slin_4915 protein of unknown function DUF1573; PFAM: Protein of unknown function DUF1573; SPTR: Putative uncharacterized protein; IMG reference gene:2504772966; PFAM: Protein of unknown function (DUF1573).
 
     0.813
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
 
     0.787
AEE50499.1
KEGG: ran:Riean_1147 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504772001.
  
     0.771
AEE52321.1
InterPro IPR003772; KEGG: phe:Phep_3814 protein of unknown function DUF177; PFAM: Protein of unknown function DUF177; SPTR: Putative uncharacterized protein; IMG reference gene:2504773867; PFAM: Uncharacterized ACR, COG1399.
  
     0.765
AEE51809.1
KEGG: cpi:Cpin_0535 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504773346.
  
     0.758
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (26%) [HD]