| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE49750.1 | AEE51555.1 | Halhy_1865 | Halhy_3703 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | 0.511 |
| AEE49750.1 | polA | Halhy_1865 | Halhy_3156 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.647 |
| AEE49750.1 | recA | Halhy_1865 | Halhy_2491 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.717 |
| AEE49750.1 | ruvB | Halhy_1865 | Halhy_6127 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.544 |
| AEE49750.1 | topA | Halhy_1865 | Halhy_5393 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.754 |
| AEE49750.1 | uvrB | Halhy_1865 | Halhy_3115 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] | 0.500 |
| AEE49750.1 | uvrC | Halhy_1865 | Halhy_2136 | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.652 |
| AEE51555.1 | AEE49750.1 | Halhy_3703 | Halhy_1865 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | UvrD/REP helicase; COGs: COG0210 Superfamily I DNA and RNA helicase; InterPro IPR000212; KEGG: chu:CHU_1554 ATP-dependent DNA helicase II; PFAM: DNA helicase, UvrD/REP type; SPTR: ATP-dependent DNA helicase II; IMG reference gene:2504771226; PFAM: UvrD/REP helicase. | 0.511 |
| AEE51555.1 | gyrA | Halhy_3703 | Halhy_5639 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.518 |
| AEE51555.1 | gyrB | Halhy_3703 | Halhy_2737 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.542 |
| AEE51555.1 | mfd | Halhy_3703 | Halhy_3470 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.655 |
| AEE51555.1 | polA | Halhy_3703 | Halhy_3156 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.512 |
| AEE51555.1 | recA | Halhy_3703 | Halhy_2491 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | Protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.493 |
| AEE51555.1 | ruvB | Halhy_3703 | Halhy_6127 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.489 |
| AEE51555.1 | topA | Halhy_3703 | Halhy_5393 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.525 |
| AEE51555.1 | uvrB | Halhy_3703 | Halhy_3115 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | UvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] | 0.981 |
| AEE51555.1 | uvrC | Halhy_3703 | Halhy_2136 | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.793 |
| gyrA | AEE51555.1 | Halhy_5639 | Halhy_3703 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | ABC transporter related protein; COGs: COG0178 Excinuclease ATPase subunit; InterPro IPR003593:IPR003439; KEGG: rci:RCIX2175 putative excinuclease ABC, ATPase subunit; PFAM: ABC transporter-like; SPTR: Putative excinuclease ABC, ATPase subunit; IMG reference gene:2504773084; PFAM: ABC transporter; TIGRFAM: excinuclease ABC, A subunit. | 0.518 |
| gyrA | gyrB | Halhy_5639 | Halhy_2737 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.973 |
| gyrA | polA | Halhy_5639 | Halhy_3156 | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.447 |
