Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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AEE52028.1Exodeoxyribonuclease III Xth; COGs: COG0708 Exonuclease III; InterPro IPR005135:IPR000097:IPR004808; KEGG: sli:Slin_0521 exodeoxyribonuclease III Xth; PFAM: Endonuclease/exonuclease/phosphatase; PRIAM: Exodeoxyribonuclease III; SPTR: Exodeoxyribonuclease III Xth; TIGRFAM: Exodeoxyribonuclease III xth; AP endonuclease, family 1; IMG reference gene:2504773568; PFAM: Endonuclease/Exonuclease/phosphatase family; TIGRFAM: exodeoxyribonuclease III; exodeoxyribonuclease III (xth). (256 aa)    
Predicted Functional Partners:
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 0.957
AEE51384.1
A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
  
 
 0.754
AEE51234.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.752
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.683
AEE51357.1
Pseudouridine synthase Rsu; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR002942:IPR000748:IPR006145; KEGG: rbi:RB2501_08660 ribosomal large subunit pseudouridine synthase B; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; SMART: RNA-binding S4; SPTR: Ribosomal large subunit pseudouridine synthase B; TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; IMG reference gene:2504772883; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase; Belongs to the pseudouridine synthase RsuA [...]
  
    0.635
AEE52673.1
Pseudouridine synthase Rsu; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR000748:IPR002942:IPR006145; KEGG: cpr:CPR_2299 ribosomal large subunit pseudouridine synthase F; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; RNA-binding S4; SMART: RNA-binding S4; SPTR: RNA pseudouridine synthase family protein; TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; IMG reference gene:2504774235; PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.
  
    0.635
AEE53905.1
Pseudouridine synthase Rsu; COGs: COG1187 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthase; InterPro IPR000748:IPR006145; KEGG: naz:Aazo_4021 pseudouridine synthase; PFAM: Pseudouridine synthase, RsuA and RluB/C/D/E/F; SPTR: Pseudouridine synthase, Rsu; TIGRFAM: Pseudouridine synthase, RsuA and RluB/E/F; IMG reference gene:2504775485; PFAM: RNA pseudouridylate synthase; TIGRFAM: pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.
  
    0.635
AEE53863.1
InterPro IPR014127; KEGG: dfe:Dfer_5052 hypothetical protein; PFAM: Conserved hypothetical protein CHP02757; SPTR: Putative uncharacterized protein; TIGRFAM: Conserved hypothetical protein CHP02757; IMG reference gene:2504775442; PFAM: Protein of unknown function (DUF2400); TIGRFAM: TIGR02757 family protein.
  
 0.633
ung
Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 0.591
AEE53221.1
PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR004013:IPR002054:IPR003583:IPR003141; KEGG: cpi:Cpin_2044 PHP domain protein; PFAM: PHP, C-terminal; SMART: Polymerase/histidinol phosphatase, N-terminal; DNA-directed DNA polymerase, family X; Helix-hairpin-helix DNA-binding motif, class 1; SPTR: PHP domain protein; IMG reference gene:2504774794; PFAM: PHP domain; Bacterial RNA polymerase, alpha chain C terminal domain.
   
 0.574
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
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