| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE51437.1 | AEE52100.1 | Halhy_3583 | Halhy_4256 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.916 |
| AEE51437.1 | AEE52331.1 | Halhy_3583 | Halhy_4491 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.735 |
| AEE51437.1 | AEE52545.1 | Halhy_3583 | Halhy_4711 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.977 |
| AEE51437.1 | AEE52546.1 | Halhy_3583 | Halhy_4712 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.900 |
| AEE51437.1 | AEE53708.1 | Halhy_3583 | Halhy_5885 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase (Uroporphyrinogen III methylase); TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504775283; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.916 |
| AEE51437.1 | hemE | Halhy_3583 | Halhy_5610 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.923 |
| AEE52099.1 | AEE52100.1 | Halhy_4255 | Halhy_4256 | Nitrite reductase (NAD(P)H), large subunit; COGs: COG1251 NAD(P)H-nitrite reductase; InterProIPR013027:IPR007419:IPR005117:IPR006067:IPR 012744; KEGG: assimilatory nitrite reductase (nad(p)h) large subunit precursor; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; BFD-like [2Fe-2S]-binding region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; Nitrite/sulphite reductase 4Fe-4S region; PRIAM: Nitrite reductase (NAD(P)H); SPTR: Nitrite reductase [NAD(P)H], large subunit; TIGRFAM: Nitrite reductase [NAD(P)H] large subunit, NirB; IMG reference g [...] | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.729 |
| AEE52099.1 | AEE53708.1 | Halhy_4255 | Halhy_5885 | Nitrite reductase (NAD(P)H), large subunit; COGs: COG1251 NAD(P)H-nitrite reductase; InterProIPR013027:IPR007419:IPR005117:IPR006067:IPR 012744; KEGG: assimilatory nitrite reductase (nad(p)h) large subunit precursor; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; BFD-like [2Fe-2S]-binding region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; Nitrite/sulphite reductase 4Fe-4S region; PRIAM: Nitrite reductase (NAD(P)H); SPTR: Nitrite reductase [NAD(P)H], large subunit; TIGRFAM: Nitrite reductase [NAD(P)H] large subunit, NirB; IMG reference g [...] | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase (Uroporphyrinogen III methylase); TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504775283; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.423 |
| AEE52100.1 | AEE51437.1 | Halhy_4256 | Halhy_3583 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | 0.916 |
| AEE52100.1 | AEE52099.1 | Halhy_4256 | Halhy_4255 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Nitrite reductase (NAD(P)H), large subunit; COGs: COG1251 NAD(P)H-nitrite reductase; InterProIPR013027:IPR007419:IPR005117:IPR006067:IPR 012744; KEGG: assimilatory nitrite reductase (nad(p)h) large subunit precursor; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; BFD-like [2Fe-2S]-binding region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; Nitrite/sulphite reductase 4Fe-4S region; PRIAM: Nitrite reductase (NAD(P)H); SPTR: Nitrite reductase [NAD(P)H], large subunit; TIGRFAM: Nitrite reductase [NAD(P)H] large subunit, NirB; IMG reference g [...] | 0.729 |
| AEE52100.1 | AEE52331.1 | Halhy_4256 | Halhy_4491 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.867 |
| AEE52100.1 | AEE52545.1 | Halhy_4256 | Halhy_4711 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.985 |
| AEE52100.1 | AEE52546.1 | Halhy_4256 | Halhy_4712 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.931 |
| AEE52100.1 | AEE53707.1 | Halhy_4256 | Halhy_5884 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR005117:IPR006067; KEGG: chu:CHU_2637 sulfite reductase (NADPH); PFAM: Nitrite/sulphite reductase 4Fe-4S region; Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like; PRIAM: Ferredoxin--nitrite reductase; SPTR: Sulfite reductase (NADPH); IMG reference gene:2504775282; PFAM: HEPN domain; Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain. | 0.919 |
| AEE52100.1 | AEE53708.1 | Halhy_4256 | Halhy_5885 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase (Uroporphyrinogen III methylase); TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504775283; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.906 |
| AEE52100.1 | AEE53709.1 | Halhy_4256 | Halhy_5886 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367; KEGG: phe:Phep_3090 siroheme synthase; SPTR: Siroheme synthase; TIGRFAM: Sirohaem synthase, N-terminal; IMG reference gene:2504775284; TIGRFAM: siroheme synthase, N-terminal domain. | 0.998 |
| AEE52100.1 | hemA | Halhy_4256 | Halhy_2780 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.712 |
| AEE52100.1 | hemE | Halhy_4256 | Halhy_5610 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.920 |
| AEE52331.1 | AEE51437.1 | Halhy_4491 | Halhy_3583 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | 0.735 |
| AEE52331.1 | AEE52100.1 | Halhy_4491 | Halhy_4256 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.867 |
