| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE49156.1 | AEE49983.1 | Halhy_1261 | Halhy_2098 | COGs: COG1956 GAF domain-containing protein; KEGG: bsb:Bresu_2759 putative GAF sensor protein; SPTR: Putative GAF sensor protein; IMG reference gene:2504770622. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
| AEE49156.1 | AEE51689.1 | Halhy_1261 | Halhy_3837 | COGs: COG1956 GAF domain-containing protein; KEGG: bsb:Bresu_2759 putative GAF sensor protein; SPTR: Putative GAF sensor protein; IMG reference gene:2504770622. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: chu:CHU_0274 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504773221; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.902 |
| AEE49156.1 | AEE52157.1 | Halhy_1261 | Halhy_4313 | COGs: COG1956 GAF domain-containing protein; KEGG: bsb:Bresu_2759 putative GAF sensor protein; SPTR: Putative GAF sensor protein; IMG reference gene:2504770622. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_5820 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504773699; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.900 |
| AEE49156.1 | metK | Halhy_1261 | Halhy_4474 | COGs: COG1956 GAF domain-containing protein; KEGG: bsb:Bresu_2759 putative GAF sensor protein; SPTR: Putative GAF sensor protein; IMG reference gene:2504770622. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| AEE49983.1 | AEE49156.1 | Halhy_2098 | Halhy_1261 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG1956 GAF domain-containing protein; KEGG: bsb:Bresu_2759 putative GAF sensor protein; SPTR: Putative GAF sensor protein; IMG reference gene:2504770622. | 0.900 |
| AEE49983.1 | AEE51689.1 | Halhy_2098 | Halhy_3837 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG2873 O-acetylhomoserine sulfhydrylase; InterPro IPR006235:IPR000277; KEGG: chu:CHU_0274 O-acetylhomoserine sulfhydrylase; PFAM: Cys/Met metabolism, pyridoxal phosphate-dependent enzyme; PRIAM: Cysteine synthase; SPTR: O-acetylhomoserine sulfhydrolase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; IMG reference gene:2504773221; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: OAH/OAS sulfhydrylase. | 0.949 |
| AEE49983.1 | AEE52157.1 | Halhy_2098 | Halhy_4313 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: sli:Slin_5820 methionine synthase vitamin-B12 independent; PFAM: Methionine synthase, vitamin-B12 independent; SPTR: Methionine synthase vitamin-B12 independent; IMG reference gene:2504773699; PFAM: Cobalamin-independent synthase, Catalytic domain. | 0.968 |
| AEE49983.1 | metK | Halhy_2098 | Halhy_4474 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.947 |
| AEE50443.1 | AEE50939.1 | Halhy_2572 | Halhy_3076 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | 0.931 |
| AEE50443.1 | AEE51071.1 | Halhy_2572 | Halhy_3211 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: fal:FRAAL0689 putative DNA modification methylase (cytosine-specific methyltransferase); PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative DNA Modification methylase (Cytosine-specific methyltransferase); TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772591; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.935 |
| AEE50443.1 | AEE53751.1 | Halhy_2572 | Halhy_5928 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | Hypothetical protein; COGs: COG0270 Site-specific DNA methylase; KEGG: sen:SACE_7029 hypothetical protein; SPTR: Gp82; IMG reference gene:2504775327; PFAM: C-5 cytosine-specific DNA methylase. | 0.900 |
| AEE50443.1 | AEE53975.1 | Halhy_2572 | Halhy_6153 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cag:Cagg_0452 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504775555; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.974 |
| AEE50443.1 | metK | Halhy_2572 | Halhy_4474 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.910 |
| AEE50939.1 | AEE50443.1 | Halhy_3076 | Halhy_2572 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | 0.931 |
| AEE50939.1 | AEE51071.1 | Halhy_3076 | Halhy_3211 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: fal:FRAAL0689 putative DNA modification methylase (cytosine-specific methyltransferase); PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative DNA Modification methylase (Cytosine-specific methyltransferase); TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772591; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.928 |
| AEE50939.1 | AEE53751.1 | Halhy_3076 | Halhy_5928 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | Hypothetical protein; COGs: COG0270 Site-specific DNA methylase; KEGG: sen:SACE_7029 hypothetical protein; SPTR: Gp82; IMG reference gene:2504775327; PFAM: C-5 cytosine-specific DNA methylase. | 0.913 |
| AEE50939.1 | AEE53975.1 | Halhy_3076 | Halhy_6153 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cag:Cagg_0452 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504775555; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.929 |
| AEE50939.1 | metK | Halhy_3076 | Halhy_4474 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.910 |
| AEE51071.1 | AEE50443.1 | Halhy_3211 | Halhy_2572 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: fal:FRAAL0689 putative DNA modification methylase (cytosine-specific methyltransferase); PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative DNA Modification methylase (Cytosine-specific methyltransferase); TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772591; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: cpi:Cpin_2562 DNA-cytosine methyltransferase; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: DNA-cytosine methyltransferase; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504771943; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | 0.935 |
| AEE51071.1 | AEE50939.1 | Halhy_3211 | Halhy_3076 | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: fal:FRAAL0689 putative DNA modification methylase (cytosine-specific methyltransferase); PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative DNA Modification methylase (Cytosine-specific methyltransferase); TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772591; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: bcg:BCG9842_B5355 modification methylase HaeIII; PFAM: DNA methylase, C-5 cytosine-specific; SPTR: Putative uncharacterized protein; TIGRFAM: DNA methylase, C-5 cytosine-specific; IMG reference gene:2504772456; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm). | 0.928 |