| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE48297.1 | tadA | Halhy_0386 | Halhy_4475 | COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: sli:Slin_1926 glycerate kinase; PFAM: Glycerate kinase; PRIAM: Glycerate kinase; SPTR: Glycerate kinase; TIGRFAM: Glycerate kinase; IMG reference gene:2504769741; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.678 |
| AEE49876.1 | hisI | Halhy_1991 | Halhy_3812 | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504773196; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.479 |
| AEE49876.1 | rsfS | Halhy_1991 | Halhy_3581 | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.531 |
| AEE49876.1 | tadA | Halhy_1991 | Halhy_4475 | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.577 |
| AEE49876.1 | tilS | Halhy_1991 | Halhy_0845 | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.496 |
| AEE52952.1 | tadA | Halhy_5126 | Halhy_4475 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: cpi:Cpin_5843 deoxynucleoside kinase; PFAM: Deoxynucleoside kinase; SPTR: Deoxynucleoside kinase; IMG reference gene:2504774524; PFAM: Deoxynucleoside kinase. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.516 |
| AEE52952.1 | tdk | Halhy_5126 | Halhy_4179 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: cpi:Cpin_5843 deoxynucleoside kinase; PFAM: Deoxynucleoside kinase; SPTR: Deoxynucleoside kinase; IMG reference gene:2504774524; PFAM: Deoxynucleoside kinase. | COGs: COG1435 Thymidine kinase; HAMAP: Thymidine kinase, subgroup; InterPro IPR020634:IPR001267; KEGG: cpi:Cpin_1517 thymidine kinase; PFAM: Thymidine kinase; PRIAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2504773565; PFAM: Thymidine kinase. | 0.543 |
| AEE53771.1 | tadA | Halhy_5948 | Halhy_4475 | COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: mtt:Ftrac_2535 phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; PRIAM: Uridine kinase; SPTR: Uridine kinase; IMG reference gene:2504775348; PFAM: Phosphoribulokinase / Uridine kinase family. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.533 |
| AEE53771.1 | tdk | Halhy_5948 | Halhy_4179 | COGs: COG0572 Uridine kinase; InterPro IPR006083; KEGG: mtt:Ftrac_2535 phosphoribulokinase/uridine kinase; PFAM: Phosphoribulokinase/uridine kinase; PRIAM: Uridine kinase; SPTR: Uridine kinase; IMG reference gene:2504775348; PFAM: Phosphoribulokinase / Uridine kinase family. | COGs: COG1435 Thymidine kinase; HAMAP: Thymidine kinase, subgroup; InterPro IPR020634:IPR001267; KEGG: cpi:Cpin_1517 thymidine kinase; PFAM: Thymidine kinase; PRIAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2504773565; PFAM: Thymidine kinase. | 0.621 |
| AEE53886.1 | tadA | Halhy_6064 | Halhy_4475 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: deoxyadenosine kinase; PFAM: Deoxynucleoside kinase; PRIAM: Deoxyadenosine kinase; SPTR: Deoxynucleoside kinase; IMG reference gene:2504775466; PFAM: Deoxynucleoside kinase. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.516 |
| AEE53886.1 | tdk | Halhy_6064 | Halhy_4179 | COGs: COG1428 Deoxynucleoside kinase; InterPro IPR002624; KEGG: deoxyadenosine kinase; PFAM: Deoxynucleoside kinase; PRIAM: Deoxyadenosine kinase; SPTR: Deoxynucleoside kinase; IMG reference gene:2504775466; PFAM: Deoxynucleoside kinase. | COGs: COG1435 Thymidine kinase; HAMAP: Thymidine kinase, subgroup; InterPro IPR020634:IPR001267; KEGG: cpi:Cpin_1517 thymidine kinase; PFAM: Thymidine kinase; PRIAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2504773565; PFAM: Thymidine kinase. | 0.621 |
| hisI | AEE49876.1 | Halhy_3812 | Halhy_1991 | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504773196; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | 0.479 |
| hisI | metK | Halhy_3812 | Halhy_4474 | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504773196; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.642 |
| hisI | tadA | Halhy_3812 | Halhy_4475 | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504773196; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.906 |
| metK | hisI | Halhy_4474 | Halhy_3812 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | COGs: COG0139 Phosphoribosyl-AMP cyclohydrolase; HAMAP: Histidine biosynthesis bifunctional protein hisIE; InterPro IPR008179:IPR002496; KEGG: mtt:Ftrac_3210 phosphoribosyl-ATP diphosphatase; PFAM: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphohydrolase; SPTR: Phosphoribosyl-ATP diphosphatase; TIGRFAM: Phosphoribosyl-ATP pyrophosphohydrolase; IMG reference gene:2504773196; PFAM: Phosphoribosyl-ATP pyrophosphohydrolase; Phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.642 |
| metK | tadA | Halhy_4474 | Halhy_4475 | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.534 |
| rsfS | AEE49876.1 | Halhy_3581 | Halhy_1991 | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | 0.531 |
| rsfS | tadA | Halhy_3581 | Halhy_4475 | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.513 |
| tadA | AEE48297.1 | Halhy_4475 | Halhy_0386 | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | COGs: COG1929 Glycerate kinase; InterPro IPR004381; KEGG: sli:Slin_1926 glycerate kinase; PFAM: Glycerate kinase; PRIAM: Glycerate kinase; SPTR: Glycerate kinase; TIGRFAM: Glycerate kinase; IMG reference gene:2504769741; PFAM: Glycerate kinase family; TIGRFAM: glycerate kinase; Belongs to the glycerate kinase type-1 family. | 0.678 |
| tadA | AEE49876.1 | Halhy_4475 | Halhy_1991 | CMP/dCMP deaminase zinc-binding protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Universal protein YeaZ; COGs: COG1214 Inactive homolog of metal-dependent protease putative molecular chaperone; InterPro IPR000905; KEGG: phe:Phep_1546 peptidase M22 glycoprotease; PFAM: Peptidase M22, glycoprotease; SPTR: Universal bacterial protein YeaZ; TIGRFAM: universal protein YeaZ; IMG reference gene:2504771357; PFAM: Glycoprotease family; TIGRFAM: universal bacterial protein YeaZ. | 0.577 |