| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE51437.1 | AEE52100.1 | Halhy_3583 | Halhy_4256 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.916 |
| AEE51437.1 | AEE52331.1 | Halhy_3583 | Halhy_4491 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.735 |
| AEE51437.1 | AEE52545.1 | Halhy_3583 | Halhy_4711 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.977 |
| AEE51437.1 | AEE52546.1 | Halhy_3583 | Halhy_4712 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.900 |
| AEE51437.1 | AEE53708.1 | Halhy_3583 | Halhy_5885 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase (Uroporphyrinogen III methylase); TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504775283; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.916 |
| AEE51437.1 | hemE | Halhy_3583 | Halhy_5610 | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.923 |
| AEE52100.1 | AEE51437.1 | Halhy_4256 | Halhy_3583 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | 0.916 |
| AEE52100.1 | AEE52331.1 | Halhy_4256 | Halhy_4491 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.867 |
| AEE52100.1 | AEE52545.1 | Halhy_4256 | Halhy_4711 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.985 |
| AEE52100.1 | AEE52546.1 | Halhy_4256 | Halhy_4712 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.931 |
| AEE52100.1 | AEE53708.1 | Halhy_4256 | Halhy_5885 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR006366:IPR000878; KEGG: phe:Phep_3091 uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase (Uroporphyrinogen III methylase); TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504775283; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.906 |
| AEE52100.1 | hemA | Halhy_4256 | Halhy_2780 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.712 |
| AEE52100.1 | hemE | Halhy_4256 | Halhy_5610 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.920 |
| AEE52100.1 | hemL | Halhy_4256 | Halhy_4539 | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | COGs: COG0001 Glutamate-1-semialdehyde aminotransferase; HAMAP: Glutamate-1-semialdehyde 2,1-aminomutase; InterPro IPR005814:IPR004639; KEGG: phe:Phep_3448 glutamate-1-semialdehyde-2,1-aminomutase; PFAM: Aminotransferase class-III; PRIAM: Glutamate-1-semialdehyde 2,1-aminomutase; SPTR: Glutamate-1-semialdehyde 2,1-aminomutase; TIGRFAM: Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase; IMG reference gene:2504773926; PFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. | 0.647 |
| AEE52330.1 | AEE52331.1 | Halhy_4490 | Halhy_4491 | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.725 |
| AEE52331.1 | AEE51437.1 | Halhy_4491 | Halhy_3583 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | COGs: COG1587 Uroporphyrinogen-III synthase; InterPro IPR003754; KEGG: zpr:ZPR_0488 uroporphyrinogen-III synthase; PFAM: Tetrapyrrole biosynthesis, uroporphyrinogen III synthase; SPTR: Uroporphyrinogen-III synthase; IMG reference gene:2504772964; PFAM: Uroporphyrinogen-III synthase HemD. | 0.735 |
| AEE52331.1 | AEE52100.1 | Halhy_4491 | Halhy_4256 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR006366; KEGG: uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole methylase; PRIAM: Uroporphyrinogen-III C-methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: Uroporphyrin-III C-methyltransferase, C-terminal; IMG reference gene:2504773642; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.867 |
| AEE52331.1 | AEE52330.1 | Halhy_4491 | Halhy_4490 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | UPF0161 protein yidD; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family. | 0.725 |
| AEE52331.1 | AEE52545.1 | Halhy_4491 | Halhy_4711 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. | 0.996 |
| AEE52331.1 | AEE52546.1 | Halhy_4491 | Halhy_4712 | Porphobilinogen synthase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: sli:Slin_5386 porphobilinogen synthase; PFAM: Tetrapyrrole biosynthesis, porphobilinogen synthase; PRIAM: Porphobilinogen synthase; SPTR: Porphobilinogen synthase; manually curated; IMG reference gene:2504773878; PFAM: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.818 |