Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
AEE52377.1Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: phe:Phep_3446 response regulator receiver; PFAM: Signal transduction response regulator, receiver region; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver region; SPTR: Response regulator receiver; IMG reference gene:2504773924; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal. (226 aa)    
Predicted Functional Partners:
AEE48009.1
COGs: COG5002 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: cpi:Cpin_1223 histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Histidine kinase; IMG reference gene:2504769446; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
 
 0.982
AEE54060.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: ppn:Palpr_1731 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Integral membrane sensor signal transduction histidine kinase; IMG reference gene:2504775647; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase [...]
  
  0.980
AEE48222.1
Histidine kinase; COGs: COG5002 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: lby:Lbys_2833 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Integral membrane sensor signal transduction histidine kinase; IMG reference gene:2504769665; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like A [...]
 
  0.977
AEE51190.1
Integral membrane sensor signal transduction histidine kinase; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterPro IPR003661:IPR003594; KEGG: fjo:Fjoh_3461 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Sensor protein RprX; IMG reference gene:2504772711; PFAM: Histidine kinase-, DNA gyrase B-, and HSP9 [...]
 
  0.976
AEE51053.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003661:IPR003594; KEGG: lby:Lbys_3178 integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Sensor protein RprX; IMG reference gene:2504772572; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
 
  0.975
AEE48008.1
Two component transcriptional regulator, winged helix family; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: zpr:ZPR_0499 two-component system response regulator; PFAM: Signal transduction response regulator, receiver region; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver region; SPTR: Two-component system response regulator; IMG reference gene:2504769445; PFAM: Response regulator receiver domain; Transcriptional regulatory [...]
  
 
 
0.917
AEE52378.1
Integral membrane sensor signal transduction histidine kinase; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterPro IPR003661:IPR003594; KEGG: cpi:Cpin_0674 histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SPTR: Histidine kinase; IMG reference gene:2504773925; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain.
 
   0.913
AEE53486.1
PAS/PAC sensor hybrid histidine kinase; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR003661:IPR003594:IPR001789:IPR 013656:IPR013767; KEGG: ppn:Palpr_2639 pas/pac sensor hybrid histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS fold-4; PAS fold; Signal transduction response regulator, receiver region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS; Signal transduction response reg [...]
 
 
0.900
AEE50547.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR000014:IPR013767:IPR003661:IPR003594; KEGG: phe:Phep_2493 PAS sensor protein; PFAM: ATP-binding region, ATPase-like; PAS fold; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; PAS; SPTR: Sensor histidine kinase; TIGRFAM: PAS; IMG reference gene:2504772050; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS [...]
 
 
 0.839
AEE48820.1
COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660:IPR003661:IPR003594; KEGG: dfe:Dfer_2761 histidine kinase; PFAM: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SMART: ATP-binding region, ATPase-like; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor region; HAMP linker domain; SPTR: Two-component system sensor histidine kinase; IMG reference gene:2504770279; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase [...]
 
   0.820
Your Current Organism:
Haliscomenobacter hydrossis
NCBI taxonomy Id: 760192
Other names: H. hydrossis DSM 1100, Haliscomenobacter hydrossis DSM 1100
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.