| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AEE50854.1 | gcvP | Halhy_2990 | Halhy_0419 | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.430 |
| AEE50854.1 | guaA | Halhy_2990 | Halhy_0188 | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.479 |
| AEE50854.1 | pdxJ | Halhy_2990 | Halhy_4556 | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.446 |
| AEE50854.1 | ribB | Halhy_2990 | Halhy_5567 | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.522 |
| AEE50985.1 | AEE51182.1 | Halhy_3123 | Halhy_3323 | Surface antigen (D15); COGs: COG4775 Outer membrane protein/protective antigen OMA87; InterPro IPR010827:IPR000184; KEGG: cpi:Cpin_1052 surface antigen variable number repeat protein; PFAM: Bacterial surface antigen (D15); Surface antigen variable number; SPTR: Bacterial surface antigen family protein; IMG reference gene:2504772503; PFAM: Surface antigen variable number repeat; TIGRFAM: outer membrane protein assembly complex, YaeT protein. | 4-hydroxythreonine-4-phosphate dehydrogenase; COGs: COG1995 Pyridoxal phosphate biosynthesis protein; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; InterPro IPR005255; KEGG: phe:Phep_3813 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; PRIAM: 4-hydroxythreonine-4-phosphate dehydrogenase; SPTR: 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; IMG reference gene:2504772703; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; TIGRFAM: 4-hydro [...] | 0.489 |
| AEE50985.1 | pdxJ | Halhy_3123 | Halhy_4556 | Surface antigen (D15); COGs: COG4775 Outer membrane protein/protective antigen OMA87; InterPro IPR010827:IPR000184; KEGG: cpi:Cpin_1052 surface antigen variable number repeat protein; PFAM: Bacterial surface antigen (D15); Surface antigen variable number; SPTR: Bacterial surface antigen family protein; IMG reference gene:2504772503; PFAM: Surface antigen variable number repeat; TIGRFAM: outer membrane protein assembly complex, YaeT protein. | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.477 |
| AEE51182.1 | AEE50985.1 | Halhy_3323 | Halhy_3123 | 4-hydroxythreonine-4-phosphate dehydrogenase; COGs: COG1995 Pyridoxal phosphate biosynthesis protein; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; InterPro IPR005255; KEGG: phe:Phep_3813 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; PRIAM: 4-hydroxythreonine-4-phosphate dehydrogenase; SPTR: 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; IMG reference gene:2504772703; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; TIGRFAM: 4-hydro [...] | Surface antigen (D15); COGs: COG4775 Outer membrane protein/protective antigen OMA87; InterPro IPR010827:IPR000184; KEGG: cpi:Cpin_1052 surface antigen variable number repeat protein; PFAM: Bacterial surface antigen (D15); Surface antigen variable number; SPTR: Bacterial surface antigen family protein; IMG reference gene:2504772503; PFAM: Surface antigen variable number repeat; TIGRFAM: outer membrane protein assembly complex, YaeT protein. | 0.489 |
| AEE51182.1 | pdxJ | Halhy_3323 | Halhy_4556 | 4-hydroxythreonine-4-phosphate dehydrogenase; COGs: COG1995 Pyridoxal phosphate biosynthesis protein; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; InterPro IPR005255; KEGG: phe:Phep_3813 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; PRIAM: 4-hydroxythreonine-4-phosphate dehydrogenase; SPTR: 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; IMG reference gene:2504772703; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; TIGRFAM: 4-hydro [...] | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.908 |
| AEE51182.1 | ribB | Halhy_3323 | Halhy_5567 | 4-hydroxythreonine-4-phosphate dehydrogenase; COGs: COG1995 Pyridoxal phosphate biosynthesis protein; HAMAP: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; InterPro IPR005255; KEGG: phe:Phep_3813 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; PRIAM: 4-hydroxythreonine-4-phosphate dehydrogenase; SPTR: 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: Pyridoxal phosphate (active vitamin B6) biosynthesis PdxA; IMG reference gene:2504772703; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; TIGRFAM: 4-hydro [...] | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.436 |
| AEE52394.1 | AEE52395.1 | Halhy_4554 | Halhy_4555 | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: pru:PRU_0045 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; IMG reference gene:2504773941; PFAM: Cytidylyltransferase family; Belongs to the CDS family. | Abortive infection protein; InterPro IPR003675; KEGG: lby:Lbys_3015 abortive infection protein; PFAM: Abortive infection protein; SPTR: Metal-dependent membrane protease; IMG reference gene:2504773942; PFAM: CAAX amino terminal protease family. | 0.785 |
| AEE52394.1 | coaD | Halhy_4554 | Halhy_4639 | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: pru:PRU_0045 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; IMG reference gene:2504773941; PFAM: Cytidylyltransferase family; Belongs to the CDS family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.465 |
| AEE52394.1 | pdxJ | Halhy_4554 | Halhy_4556 | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: pru:PRU_0045 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; IMG reference gene:2504773941; PFAM: Cytidylyltransferase family; Belongs to the CDS family. | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.477 |
| AEE52395.1 | AEE52394.1 | Halhy_4555 | Halhy_4554 | Abortive infection protein; InterPro IPR003675; KEGG: lby:Lbys_3015 abortive infection protein; PFAM: Abortive infection protein; SPTR: Metal-dependent membrane protease; IMG reference gene:2504773942; PFAM: CAAX amino terminal protease family. | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: pru:PRU_0045 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; IMG reference gene:2504773941; PFAM: Cytidylyltransferase family; Belongs to the CDS family. | 0.785 |
| AEE52395.1 | pdxJ | Halhy_4555 | Halhy_4556 | Abortive infection protein; InterPro IPR003675; KEGG: lby:Lbys_3015 abortive infection protein; PFAM: Abortive infection protein; SPTR: Metal-dependent membrane protease; IMG reference gene:2504773942; PFAM: CAAX amino terminal protease family. | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.545 |
| coaD | AEE52394.1 | Halhy_4639 | Halhy_4554 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Phosphatidate cytidylyltransferase; COGs: COG0575 CDP-diglyceride synthetase; InterPro IPR000374; KEGG: pru:PRU_0045 phosphatidate cytidylyltransferase; PFAM: Phosphatidate cytidylyltransferase; SPTR: Phosphatidate cytidylyltransferase; IMG reference gene:2504773941; PFAM: Cytidylyltransferase family; Belongs to the CDS family. | 0.465 |
| coaD | guaA | Halhy_4639 | Halhy_0188 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.735 |
| coaD | pdxJ | Halhy_4639 | Halhy_4556 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. | 0.461 |
| coaD | ribB | Halhy_4639 | Halhy_5567 | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.417 |
| gcvP | AEE50854.1 | Halhy_0419 | Halhy_2990 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | COGs: COG0527 Aspartokinase; InterProIPR001048:IPR002912:IPR005106:IPR001342:IPR 001341; KEGG: chu:CHU_0073 bifunctional aspartokinase I/homeserine dehydrogenase I; PFAM: Homoserine dehydrogenase, catalytic; Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Aspartate/homoserine dehydrogenase, NAD-binding; PRIAM: Aspartate kinase., Homoserine dehydrogenase; SPTR: Bifunctional protein: aspartokinase I; homoserine dehydrogenase; TIGRFAM: Aspartate kinase region; IMG reference gene:2504772364; PFAM: Homoserine dehydrogenase; Homoserine dehydrogenase, NAD binding domain; ACT dom [...] | 0.430 |
| gcvP | guaA | Halhy_0419 | Halhy_0188 | Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.481 |
