STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purA-2Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (397 aa)    
Predicted Functional Partners:
OLZ55509.1
Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.961
OLZ51054.1
Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
   0.953
OLZ51055.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.951
purH
Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.951
guaB
IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.938
OLZ47652.1
3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.930
OLZ53568.1
Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.926
OLZ49055.1
Inosine 5-monophosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.884
OLZ55276.1
Hypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.856
guaA
Serine/arginine repetitive matrix protein 1; Catalyzes the synthesis of GMP from XMP.
 
  
 0.853
Your Current Organism:
Amycolatopsis coloradensis
NCBI taxonomy Id: 76021
Other names: A. coloradensis, ATCC 53629, Amycolatopsis coloradoensis, DSM 44225, IFO 15804, IMSNU 22096, JCM 9869, NBRC 15804, NRRL 3218
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