AEG16915.1 protein (Desulfofundulus kuznetsovii)

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Known Interactions

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Predicted Interactions

gene neighborhood

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gene co-occurrence

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Score

AEG16915.1

Regulatory protein MerR; KEGG: dau:Daud_1710 resolvase domain-containing protein; PFAM: HTH transcriptional regulator, MerR; Resolvase, N-terminal; SMART: HTH transcriptional regulator, MerR. (168 aa)

Predicted Functional Partners:

AEG16914.1

0.820

AEG16331.1

0.661

AEG13942.1

0.660

AEG16727.1

0.651

AEG15624.1

0.639

AEG16916.1

0.543

AEG14347.1

0.526

AEG13886.1

0.456

AEG16295.1

0.442

AEG16730.1

0.437

Your Current Organism:

Desulfofundulus kuznetsovii

NCBI taxonomy Id: 760568
Other names: D. kuznetsovii DSM 6115, Desulfofundulus kuznetsovii DSM 6115, Desulfotomaculum kuznetsovii 17, Desulfotomaculum kuznetsovii DSM 6115

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEG13886.1	AEG13942.1	Desku_0250	Desku_0312	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.457
AEG13886.1	AEG15624.1	Desku_0250	Desku_2072	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.458
AEG13886.1	AEG16331.1	Desku_0250	Desku_2820	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.459
AEG13886.1	AEG16727.1	Desku_0250	Desku_3238	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.465
AEG13886.1	AEG16914.1	Desku_0250	Desku_3433	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.455
AEG13886.1	AEG16915.1	Desku_0250	Desku_3435	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	Regulatory protein MerR; KEGG: dau:Daud_1710 resolvase domain-containing protein; PFAM: HTH transcriptional regulator, MerR; Resolvase, N-terminal; SMART: HTH transcriptional regulator, MerR.	0.456
AEG13942.1	AEG13886.1	Desku_0312	Desku_0250	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	0.457
AEG13942.1	AEG14347.1	Desku_0312	Desku_0740	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	0.465
AEG13942.1	AEG16295.1	Desku_0312	Desku_2783	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	KEGG: dau:Daud_1910 hypothetical protein.	0.498
AEG13942.1	AEG16730.1	Desku_0312	Desku_3241	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	KEGG: dau:Daud_1910 hypothetical protein.	0.488
AEG13942.1	AEG16915.1	Desku_0312	Desku_3435	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	Regulatory protein MerR; KEGG: dau:Daud_1710 resolvase domain-containing protein; PFAM: HTH transcriptional regulator, MerR; Resolvase, N-terminal; SMART: HTH transcriptional regulator, MerR.	0.660
AEG14347.1	AEG13942.1	Desku_0740	Desku_0312	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.465
AEG14347.1	AEG15624.1	Desku_0740	Desku_2072	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.469
AEG14347.1	AEG16331.1	Desku_0740	Desku_2820	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.467
AEG14347.1	AEG16727.1	Desku_0740	Desku_3238	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.462
AEG14347.1	AEG16914.1	Desku_0740	Desku_3433	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	0.468
AEG14347.1	AEG16915.1	Desku_0740	Desku_3435	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	Regulatory protein MerR; KEGG: dau:Daud_1710 resolvase domain-containing protein; PFAM: HTH transcriptional regulator, MerR; Resolvase, N-terminal; SMART: HTH transcriptional regulator, MerR.	0.526
AEG15624.1	AEG13886.1	Desku_2072	Desku_0250	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	TIGRFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0427 transposase, IS605 OrfB family.	0.458
AEG15624.1	AEG14347.1	Desku_2072	Desku_0740	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	PFAM: Transposase, IS605 OrfB, C-terminal; Transposase, probable, IS891/IS1136/IS1341; KEGG: mev:Metev_1801 IS605 OrfB family transposase.	0.469
AEG15624.1	AEG16295.1	Desku_2072	Desku_2783	PFAM: Transposase, IS605 OrfB, C-terminal; KEGG: adg:Adeg_0745 transposase IS605 OrfB.	KEGG: dau:Daud_1910 hypothetical protein.	0.470

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.773

expected number of edges:

19

PPI enrichment p-value:

0.00874

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009435

NAD biosynthetic process

3 of 7

2.16

1.33

0.0030

GO:0009165

Nucleotide biosynthetic process

4 of 84

1.2

0.77

0.0122

GO:0043648

Dicarboxylic acid metabolic process

3 of 41

1.39

0.75

0.0237

GO:0044281

Small molecule metabolic process

8 of 558

0.68

0.5

0.0048

GO:1901566

Organonitrogen compound biosynthetic process

7 of 469

0.7

0.47

0.0132

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

3 of 7

2.16

1.44

0.0018

GO:0019842

Vitamin binding

4 of 51

1.42

1.05

0.0034

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 23

1.64

1.02

0.0075

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30647460

(2019) Fueled by methane: deep-sea sponges from asphalt seeps gain their nutrition from methane-oxidizing symbionts.

3 of 32

1.5

1.35

0.00060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1920

Pyridine nucleotide biosynthetic process

3 of 5

2.31

1.78

0.00044

CL:1080

Citrate cycle (TCA cycle), and Glutamate synthase domain

4 of 31

1.64

1.45

0.00057

CL:1078

Mixed, incl. Citrate cycle (TCA cycle), and Oxaloacetate decarboxylase activity

5 of 56

1.48

1.4

0.00036

CL:1120

Pyruvate ferredoxin/flavodoxin oxidoreductase, and Glutamate synthase domain

2 of 6

2.05

0.98

0.0140

CL:1582

Carboxylic acid biosynthetic process, and Nucleotide biosynthetic process

6 of 186

1.04

0.87

0.0012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

4 of 26

1.71

1.73

0.00014

map00250

Alanine, aspartate and glutamate metabolism

4 of 27

1.7

1.72

0.00014

map00760

Nicotinate and nicotinamide metabolism

3 of 39

1.41

0.99

0.0051

map00620

Pyruvate metabolism

3 of 48

1.32

0.89

0.0076

map00220

Arginine biosynthesis

2 of 17

1.6

0.83

0.0204

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

3 of 15

1.83

1.22

0.0035

KW-0662

Pyridine nucleotide biosynthesis

2 of 3

2.35

1.11

0.0091

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17147

Pyruvate:ferredoxin oxidoreductase core domain II

2 of 2

2.53

0.84

0.0294

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 2

2.53

0.84

0.0294

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 2

2.53

0.84

0.0294

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

2 of 5

2.13

0.82

0.0294

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

3 of 10

2.0

1.08

0.0087

IPR033412

Pyruvate:ferredoxin oxidoreductase, core domain II

2 of 2

2.53

0.78

0.0379

IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain

2 of 2

2.53

0.78

0.0379

IPR002880

Pyruvate flavodoxin/ferredoxin oxidoreductase, pyrimidine binding domain

2 of 2

2.53

0.78

0.0379

IPR002869

Pyruvate-flavodoxin oxidoreductase, central domain

2 of 2

2.53

0.78

0.0379

(more ...)

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