| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| argG | nadB | ebA5097 | ebA5461 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. | 0.914 |
| argG | purA | ebA5097 | ebA1249 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.937 |
| argG | purL | ebA5097 | ebA6142 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Phosphoribosylformylglycinamidine synthase (FGAM synthase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.525 |
| argG | pyrB | ebA5097 | ebA1759 | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.910 |
| ebA3304 | guaA | ebA3304 | ebA6645 | Putative hypoxanthine phosphoribosyltransferase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.957 |
| ebA3304 | guaB | ebA3304 | ebA6647 | Putative hypoxanthine phosphoribosyltransferase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.939 |
| ebA3304 | purA | ebA3304 | ebA1249 | Putative hypoxanthine phosphoribosyltransferase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.942 |
| ebA3304 | purH | ebA3304 | ebA1153 | Putative hypoxanthine phosphoribosyltransferase. | Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)]. | 0.935 |
| ebA3304 | purL | ebA3304 | ebA6142 | Putative hypoxanthine phosphoribosyltransferase. | Phosphoribosylformylglycinamidine synthase (FGAM synthase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.461 |
| ebA3304 | surE | ebA3304 | ebA782 | Putative hypoxanthine phosphoribosyltransferase. | Acid phosphatase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.912 |
| guaA | ebA3304 | ebA6645 | ebA3304 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Putative hypoxanthine phosphoribosyltransferase. | 0.957 |
| guaA | guaB | ebA6645 | ebA6647 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
| guaA | purA | ebA6645 | ebA1249 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.941 |
| guaA | purB | ebA6645 | ebA1420 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.868 |
| guaA | purH | ebA6645 | ebA1153 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)]. | 0.897 |
| guaA | purL | ebA6645 | ebA6142 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformylglycinamidine synthase (FGAM synthase); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.956 |
| guaA | pyrB | ebA6645 | ebA1759 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.633 |
| guaA | surE | ebA6645 | ebA782 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Acid phosphatase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.954 |
| guaB | ebA3304 | ebA6647 | ebA3304 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Putative hypoxanthine phosphoribosyltransferase. | 0.939 |
| guaB | guaA | ebA6647 | ebA6645 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.999 |