pth protein (Aromatoleum aromaticum) - STRING interaction network

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pth

peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (196 aa)

Predicted Functional Partners:

ychF

0.895

rplY

0.848

prfA

0.732

prfB

0.730

mfd

0.727

rplM

0.680

prs

0.633

guaA

0.614

frr

0.600

rpmA

0.597

Your Current Organism:

Aromatoleum aromaticum

NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
frr	guaA	ebA5990	ebA6645	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	GMP synthase; Catalyzes the synthesis of GMP from XMP.	0.632
frr	prfA	ebA5990	ebA1177	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.924
frr	prfB	ebA5990	ebA5809	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	Peptide chain release factor 2 (RF-2),gene containing programmed frameshift site; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.	0.923
frr	pth	ebA5990	ebA1411	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.	0.600
frr	rplM	ebA5990	ebA938	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.977
frr	rplY	ebA5990	ebA1409	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	50S Ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.	0.843
frr	rpmA	ebA5990	ebC2	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.956
guaA	frr	ebA6645	ebA5990	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	0.632
guaA	prfB	ebA6645	ebA5809	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Peptide chain release factor 2 (RF-2),gene containing programmed frameshift site; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.	0.459
guaA	prs	ebA6645	ebA1406	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Phosphoribosyl transferase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.758
guaA	pth	ebA6645	ebA1411	GMP synthase; Catalyzes the synthesis of GMP from XMP.	peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.	0.614
guaA	rplM	ebA6645	ebA938	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.834
guaA	rplY	ebA6645	ebA1409	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S Ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.	0.534
guaA	rpmA	ebA6645	ebC2	GMP synthase; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.472
guaA	ychF	ebA6645	ebA4139	GMP synthase; Catalyzes the synthesis of GMP from XMP.	Predicted GTPase, probably involved in regulation of ribosome function; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.	0.841
mfd	prfB	ebA6555	ebA5809	Transcription-repair coupling protein Mfd; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.	Peptide chain release factor 2 (RF-2),gene containing programmed frameshift site; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.	0.757
mfd	pth	ebA6555	ebA1411	Transcription-repair coupling protein Mfd; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.	peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.	0.727
prfA	frr	ebA1177	ebA5990	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.	0.924
prfA	prfB	ebA1177	ebA5809	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Peptide chain release factor 2 (RF-2),gene containing programmed frameshift site; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.	0.837
prfA	prs	ebA1177	ebA1406	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Phosphoribosyl transferase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.563

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