| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carB | pyrB | ebA4815 | ebA1759 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carB | pyrE | ebA4815 | ebA3324 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.916 |
| carB | pyrF | ebA4815 | ebA2293 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.918 |
| carB | pyrH | ebA4815 | ebA5988 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.435 |
| carB | pyrR | ebA4815 | ebA1757 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Phosphoribosyl transferase. | 0.855 |
| carB | pyrX | ebA4815 | ebA1760 | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | Dihydroorotase-like protein. | 0.914 |
| ebA1756 | pyrB | ebA1756 | ebA1759 | Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.877 |
| ebA1756 | pyrR | ebA1756 | ebA1757 | Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. | Phosphoribosyl transferase. | 0.836 |
| ebA1756 | pyrX | ebA1756 | ebA1760 | Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. | Dihydroorotase-like protein. | 0.844 |
| ebA3966 | pyrF | ebA3966 | ebA2293 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.900 |
| ebA3966 | pyrH | ebA3966 | ebA5988 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.900 |
| ebA3966 | pyrR | ebA3966 | ebA1757 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Phosphoribosyl transferase. | 0.902 |
| ebA3966 | surE | ebA3966 | ebA782 | Nucleotide-binding protein implicated in inhibition of septum formation; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Acid phosphatase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| ppnP | pyrR | ebD86 | ebA1757 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Phosphoribosyl transferase. | 0.911 |
| ppnP | surE | ebD86 | ebA782 | Conserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. | Acid phosphatase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| pyrB | carB | ebA1759 | ebA4815 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. | 0.999 |
| pyrB | ebA1756 | ebA1759 | ebA1756 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. | 0.877 |
| pyrB | pyrE | ebA1759 | ebA3324 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.905 |
| pyrB | pyrF | ebA1759 | ebA2293 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotidine 5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. | 0.906 |
| pyrB | pyrH | ebA1759 | ebA5988 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.502 |