STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
icmFPutative adenosyl-cobalamine enzyme similar to methylmalonyl-CoA mutase or isobutyryl-CoA mutase; Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly. (1099 aa)    
Predicted Functional Partners:
sbmB
Methylmalonyl-CoA mutase, beta subunit.
 
 
0.991
SbmB
Methylmalonyl-CoA mutase, C-terminal domain/subunit (Cobalamin-binding).
 
0.925
sbmA
Methylmalonyl-CoA mutase subunit alpha.
 
 
0.889
ebA2092
Conserved hypothetical protein.
 
  
0.855
argK
LAO/AO transport system kinase.
 
  
0.849
ebA3624
Predicted ABC-type Fe3+-hydroxamate transport system, periplasmic component.
 
  
 0.802
lepA
GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
     
 0.699
sdhA
Succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
     
 0.683
lepB
Signal peptidase I (SPase I) transmembrane protein; Belongs to the peptidase S26 family.
     
 0.678
ebA2315
Fusion of 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase.
 
  
 0.674
Your Current Organism:
Aromatoleum aromaticum
NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.