Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
birAProbable biotin--acetyl-CoA-carboxylase ligase. (269 aa)    
Predicted Functional Partners:
coaX
Transcriptional regulator, Bvg acessory factor; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
    0.971
bioB
Biotin synthase protein (EC 2.8.1.6),gene: BIOB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
 
 0.942
accC
Putative biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
 
 0.848
ebA4659
Putative acyl-CoA carboxylase alpha chain protein.
 
  
 0.699
xccC-2
Biotin carboxylase subunit of unknown acetyl-CoA carboxylase-like enzyme.
 
  
 0.684
xccC
Biotin carboxylase subunit of acetyl-CoA carboxylase-like enzyme.
 
  
 0.678
pccA
Propionyl-CoA carboxylase, alpha subunit.
 
  
 0.673
trpB-2
Pyridoxal-phosphate dependent enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.630
ebA6494
Probable glycoprotease.
 
    0.626
fabD
Probable malonyl CoA-[acyl-carrier-protein] transacylase.
 
   
 0.618
Your Current Organism:
Aromatoleum aromaticum
NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1
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