Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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iscUIscU protein involved in Fe-S cluster formation; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (126 aa)    
Predicted Functional Partners:
iscS
Cysteine desulfurase involved in Fe-S cluster formation (EC 4.4.1.-); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
 
 0.998
hscB
Chaperone protein HscB involved in Fe-S cluster synthesis (DnaJ paralog); Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 0.997
iscS1
Putative cysteine desulfurase involved in Fe-S cluster formation.
 
 0.995
fdx
2Fe-2S ferredoxin involved in the assembly of Fe-S clusters.
 
 0.994
hscA
Chaperone protein HscA, involved in Fe-S cluster synthesis (DnaK paralog); Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
 
 0.976
ebA6367
Putative aminotransferase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
  
 0.973
iscA
IscA protein involved in Fe-S cluster synthesis; Belongs to the HesB/IscA family.
 
 
 0.970
ebA6395
Conserved hypothetical protein.
 
 
 0.948
iscR
Iron-sulphur cluster assembly transcription factor IscR.
 
  
 0.930
ascD
CDP-6-deoxy-L-threo-D-glycero-4-hexulose-3-dehyd rase reductase.
  
 0.743
Your Current Organism:
Aromatoleum aromaticum
NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1
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