STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase involved in Fe-S cluster formation (EC 4.4.1.-); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (403 aa)    
Predicted Functional Partners:
iscU
IscU protein involved in Fe-S cluster formation; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.998
fdx
2Fe-2S ferredoxin involved in the assembly of Fe-S clusters.
 
 0.979
iscS1
Putative cysteine desulfurase involved in Fe-S cluster formation.
 
  
 
0.978
hscB
Chaperone protein HscB involved in Fe-S cluster synthesis (DnaJ paralog); Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.969
iscA
IscA protein involved in Fe-S cluster synthesis; Belongs to the HesB/IscA family.
 
  
 0.950
thiF
Adenylyltransferase.
   
 0.945
ebA2443
Similar to thiamine biosynthesis protein.
   
 0.945
ebD53
Possible NifU homolog.
  
 0.942
iscR
Iron-sulphur cluster assembly transcription factor IscR.
 
  
 0.933
tst
Thiosulfate sulfurtransferase.
  
 0.921
Your Current Organism:
Aromatoleum aromaticum
NCBI taxonomy Id: 76114
Other names: A. aromaticum EbN1, Aromatoleum aromaticum EbN1, Aromatoleum aromaticum str. EbN1, Aromatoleum aromaticum strain EbN1, Azoarcus sp. EbN1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.