AEI49772.1 protein (Runella slithyformis) - STRING interaction network

Nodes:

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

AEI49772.1

Lipopolysaccharide biosynthesis protein. (735 aa)

Predicted Functional Partners:

AEI49766.1

0.835

AEI49780.1

0.808

AEI49771.1

0.792

AEI49765.1

0.782

AEI49769.1

0.765

AEI49773.1

0.748

AEI49764.1

0.700

AEI49774.1

0.696

AEI49768.1

0.662

AEI48986.1

0.637

Your Current Organism:

Runella slithyformis

NCBI taxonomy Id: 761193
Other names: R. slithyformis DSM 19594, Runella slithyformis DSM 19594, Runella slithyformis str. DSM 19594, Runella slithyformis strain DSM 19594

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEI48986.1	AEI49772.1	Runsl_2585	Runsl_3406	Anthranilate phosphoribosyltransferase-like protein.	Lipopolysaccharide biosynthesis protein.	0.637
AEI49764.1	AEI49765.1	Runsl_3398	Runsl_3399	Glycosyl transferase family 2.	Glycosyl transferase family 2.	0.940
AEI49764.1	AEI49766.1	Runsl_3398	Runsl_3400	Glycosyl transferase family 2.	O-antigen polymerase.	0.923
AEI49764.1	AEI49768.1	Runsl_3398	Runsl_3402	Glycosyl transferase family 2.	Acetyltransferase (isoleucine patch superfamily)-like protein.	0.431
AEI49764.1	AEI49769.1	Runsl_3398	Runsl_3403	Glycosyl transferase family 2.	Glycosyl transferase group 1.	0.795
AEI49764.1	AEI49772.1	Runsl_3398	Runsl_3406	Glycosyl transferase family 2.	Lipopolysaccharide biosynthesis protein.	0.700
AEI49764.1	AEI49780.1	Runsl_3398	Runsl_3414	Glycosyl transferase family 2.	Glycosyl transferase family 2.	0.769
AEI49765.1	AEI49764.1	Runsl_3399	Runsl_3398	Glycosyl transferase family 2.	Glycosyl transferase family 2.	0.940
AEI49765.1	AEI49766.1	Runsl_3399	Runsl_3400	Glycosyl transferase family 2.	O-antigen polymerase.	0.932
AEI49765.1	AEI49768.1	Runsl_3399	Runsl_3402	Glycosyl transferase family 2.	Acetyltransferase (isoleucine patch superfamily)-like protein.	0.620
AEI49765.1	AEI49769.1	Runsl_3399	Runsl_3403	Glycosyl transferase family 2.	Glycosyl transferase group 1.	0.767
AEI49765.1	AEI49772.1	Runsl_3399	Runsl_3406	Glycosyl transferase family 2.	Lipopolysaccharide biosynthesis protein.	0.782
AEI49765.1	AEI49780.1	Runsl_3399	Runsl_3414	Glycosyl transferase family 2.	Glycosyl transferase family 2.	0.791
AEI49766.1	AEI49764.1	Runsl_3400	Runsl_3398	O-antigen polymerase.	Glycosyl transferase family 2.	0.923
AEI49766.1	AEI49765.1	Runsl_3400	Runsl_3399	O-antigen polymerase.	Glycosyl transferase family 2.	0.932
AEI49766.1	AEI49768.1	Runsl_3400	Runsl_3402	O-antigen polymerase.	Acetyltransferase (isoleucine patch superfamily)-like protein.	0.536
AEI49766.1	AEI49769.1	Runsl_3400	Runsl_3403	O-antigen polymerase.	Glycosyl transferase group 1.	0.806
AEI49766.1	AEI49772.1	Runsl_3400	Runsl_3406	O-antigen polymerase.	Lipopolysaccharide biosynthesis protein.	0.835
AEI49766.1	AEI49780.1	Runsl_3400	Runsl_3414	O-antigen polymerase.	Glycosyl transferase family 2.	0.807
AEI49768.1	AEI49764.1	Runsl_3402	Runsl_3398	Acetyltransferase (isoleucine patch superfamily)-like protein.	Glycosyl transferase family 2.	0.431

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.82

expected number of edges:

11

PPI enrichment p-value:

0.00876

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006569

Tryptophan catabolic process

5 of 14

2.82

4.88

7.47e-10

GO:0034354

De novo NAD biosynthetic process from tryptophan

5 of 16

2.77

4.85

7.47e-10

GO:0042537

Benzene-containing compound metabolic process

5 of 46

2.31

4.0

7.88e-09

GO:0043420

Anthranilate metabolic process

3 of 5

3.05

3.3

9.72e-07

GO:0019805

Quinolinate biosynthetic process

3 of 5

3.05

3.3

9.72e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004502

Kynurenine 3-monooxygenase activity

3 of 3

3.27

2.93

5.05e-06

GO:0004474

Malate synthase activity

2 of 4

2.97

1.4

0.0029

GO:0046564

Oxalate decarboxylase activity

2 of 5

2.87

1.39

0.0030

GO:0071949

FAD binding

3 of 147

1.58

0.79

0.0250

GO:0003824

Catalytic activity

11 of 8442

0.39

0.28

0.0250

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009514

Glyoxysome

2 of 6

2.79

1.18

0.0072

GO:0005782

Peroxisomal matrix

2 of 19

2.29

0.97

0.0161

GO:0005741

Mitochondrial outer membrane

3 of 119

1.67

0.89

0.0161

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27157477

(2016) Transcriptomic profile of tobacco in response to Alternaria longipes and Alternaria alternata infections.

2 of 2

3.27

1.97

0.00028

PMID:35205907

(2022) Lauric Acid Induces Apoptosis of Rice Sheath Blight Disease Caused by Rhizoctonia solani by Affecting Fungal Fatty Acid Metabolism and Destroying the Dynamic Equilibrium of Reactive Oxygen Species.

2 of 14

2.43

1.38

0.0028

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22640

Tryptophan catabolic process, and Kynurenic acid metabolic process

5 of 10

2.97

5.28

1.65e-10

CL:22189

Mixed, incl. DapA-like, and D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain

5 of 58

2.21

3.38

1.27e-07

CL:22283

Phosphoenolpyruvate carboxykinase, and Formate catabolic process

3 of 8

2.85

2.79

7.62e-06

CL:22642

Kynurenine 3-monooxygenase activity, and Kynurenic acid metabolic process

2 of 5

2.87

1.53

0.0017

CL:22198

Isocitrate lyase, and Dihydrodipicolinate synthetase family

2 of 22

2.23

0.92

0.0201

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00630

Glyoxylate and dicarboxylate metabolism

7 of 162

1.91

3.95

1.14e-10

map00380

Tryptophan metabolism

5 of 158

1.77

2.51

1.04e-06

map01200

Carbon metabolism

4 of 415

1.26

1.01

0.0020

map01100

Metabolic pathways

11 of 5771

0.55

0.48

4.56e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71240

Tryptophan catabolism

4 of 75

2.0

2.06

6.44e-05

MAP-71291

Metabolism of amino acids and derivatives

5 of 650

1.16

0.82

0.0063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009514

Glyoxysome

2 of 6

2.79

1.13

0.0089

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0329

Glyoxylate bypass

2 of 2

3.27

1.88

0.00041

KW-0816

Tricarboxylic acid cycle

2 of 12

2.49

1.36

0.0031

KW-0464

Manganese

2 of 23

2.21

1.16

0.0067

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01274

Malate synthase

2 of 2

3.27

1.33

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046363

Malate synthase, N-terminal and TIM-barrel domains

2 of 2

3.27

1.11

0.0103

IPR044856

Malate synthase, C-terminal superfamily

2 of 2

3.27

1.11

0.0103

IPR019830

Malate synthase, conserved site

2 of 2

3.27

1.11

0.0103

IPR011076

Malate synthase superfamily

2 of 2

3.27

1.11

0.0103

IPR006252

Malate synthase A

2 of 2

3.27

1.11

0.0103

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00835

Cupin

2 of 9

2.62

1.16

0.0077

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