AEI51836.1 protein (Runella slithyformis) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

AEI51836.1

Putative lipase. (235 aa)

Predicted Functional Partners:

AEI50554.1

0.705

AEI48975.1

0.567

AEI49038.1

0.551

AEI49313.1

0.533

AEI50582.1

0.441

AEI51833.1

0.436

AEI49132.1

0.433

AEI49141.1

0.432

AEI49029.1

0.419

AEI50700.1

0.406

Your Current Organism:

Runella slithyformis

NCBI taxonomy Id: 761193
Other names: R. slithyformis DSM 19594, Runella slithyformis DSM 19594, Runella slithyformis str. DSM 19594, Runella slithyformis strain DSM 19594

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AEI48975.1	AEI51836.1	Runsl_2574	Runsl_5546	Arylsulfatase.	Putative lipase.	0.567
AEI49029.1	AEI50554.1	Runsl_2629	Runsl_4210	Hypothetical protein.	Hypothetical protein.	0.522
AEI49029.1	AEI51836.1	Runsl_2629	Runsl_5546	Hypothetical protein.	Putative lipase.	0.419
AEI49038.1	AEI50554.1	Runsl_2638	Runsl_4210	Hypothetical protein.	Hypothetical protein.	0.692
AEI49038.1	AEI51836.1	Runsl_2638	Runsl_5546	Hypothetical protein.	Putative lipase.	0.551
AEI49132.1	AEI49141.1	Runsl_2735	Runsl_2744	Two component regulator propeller domain protein.	PhoPQ-activated pathogenicity-related protein PqaA type.	0.781
AEI49132.1	AEI49313.1	Runsl_2735	Runsl_2925	Two component regulator propeller domain protein.	PHP domain protein.	0.558
AEI49132.1	AEI50554.1	Runsl_2735	Runsl_4210	Two component regulator propeller domain protein.	Hypothetical protein.	0.532
AEI49132.1	AEI51833.1	Runsl_2735	Runsl_5543	Two component regulator propeller domain protein.	Protein of unknown function DUF1549.	0.740
AEI49132.1	AEI51836.1	Runsl_2735	Runsl_5546	Two component regulator propeller domain protein.	Putative lipase.	0.433
AEI49141.1	AEI49132.1	Runsl_2744	Runsl_2735	PhoPQ-activated pathogenicity-related protein PqaA type.	Two component regulator propeller domain protein.	0.781
AEI49141.1	AEI51833.1	Runsl_2744	Runsl_5543	PhoPQ-activated pathogenicity-related protein PqaA type.	Protein of unknown function DUF1549.	0.490
AEI49141.1	AEI51836.1	Runsl_2744	Runsl_5546	PhoPQ-activated pathogenicity-related protein PqaA type.	Putative lipase.	0.432
AEI49313.1	AEI49132.1	Runsl_2925	Runsl_2735	PHP domain protein.	Two component regulator propeller domain protein.	0.558
AEI49313.1	AEI50554.1	Runsl_2925	Runsl_4210	PHP domain protein.	Hypothetical protein.	0.714
AEI49313.1	AEI51833.1	Runsl_2925	Runsl_5543	PHP domain protein.	Protein of unknown function DUF1549.	0.452
AEI49313.1	AEI51836.1	Runsl_2925	Runsl_5546	PHP domain protein.	Putative lipase.	0.533
AEI50554.1	AEI49029.1	Runsl_4210	Runsl_2629	Hypothetical protein.	Hypothetical protein.	0.522
AEI50554.1	AEI49038.1	Runsl_4210	Runsl_2638	Hypothetical protein.	Hypothetical protein.	0.692
AEI50554.1	AEI49132.1	Runsl_4210	Runsl_2735	Hypothetical protein.	Two component regulator propeller domain protein.	0.532

page 1 of 2

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.213

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 21

1.73

1.67

0.00022

GO:0006090

Pyruvate metabolic process

4 of 23

1.69

1.64

0.00022

GO:0006091

Generation of precursor metabolites and energy

8 of 137

1.22

1.47

3.30e-06

GO:0005975

Carbohydrate metabolic process

6 of 98

1.24

1.26

0.00012

GO:0006096

Glycolytic process

3 of 16

1.73

1.19

0.0036

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

2 of 2

2.45

0.99

0.0155

GO:0004611

Phosphoenolpyruvate carboxykinase activity

2 of 2

2.45

0.99

0.0155

GO:0046872

Metal ion binding

8 of 431

0.72

0.49

0.0108

GO:0043167

Ion binding

9 of 831

0.49

0.32

0.0305

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36747056

(2023) Complex regulation in a Comamonas platform for diverse aromatic carbon metabolism.

3 of 9

1.98

1.53

0.00094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1873

Mixed, incl. Carbon metabolism, and Branched-chain amino acid biosynthetic process

9 of 118

1.34

2.03

7.89e-09

CL:1877

Citrate cycle (TCA cycle), and 3Fe-4S

4 of 25

1.66

1.59

0.00026

CL:1876

Citrate cycle (TCA cycle), and Alanine, aspartate and glutamate metabolism

5 of 46

1.49

1.56

0.00011

CL:2062

Glycolysis

3 of 10

1.93

1.5

0.0010

CL:1874

Mixed, incl. Citrate cycle (TCA cycle), and Alpha-amino acid metabolic process

6 of 92

1.27

1.3

0.00011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00680

Methane metabolism

5 of 29

1.69

2.34

1.52e-06

map00010

Glycolysis / Gluconeogenesis

5 of 33

1.63

2.21

2.18e-06

map01200

Carbon metabolism

9 of 114

1.35

2.19

6.25e-10

map00620

Pyruvate metabolism

6 of 53

1.51

2.12

6.13e-07

map01120

Microbial metabolism in diverse environments

11 of 288

1.04

1.36

6.25e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

3 of 9

1.98

1.44

0.0015

KW-0670

Pyruvate

3 of 12

1.85

1.39

0.0015

KW-0816

Tricarboxylic acid cycle

3 of 13

1.82

1.38

0.0015

KW-0460

Magnesium

5 of 89

1.2

1.0

0.0015

KW-0418

Kinase

4 of 86

1.12

0.77

0.0080

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily

3 of 8

2.03

1.14

0.0065

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