STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egtDMethyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family. (321 aa)    
Predicted Functional Partners:
egtB
Sulfatase-modifying factor 1; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family.
 
 0.999
egtC
Glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
 
 0.995
egtA
Glutamate--cysteine ligase; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine.
 
  
 0.984
egtE
Pyridoxal-phosphate-dependent transferase; Probably catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.
  
  
 0.982
CQD11178.1
Sulfatase-modifying factor 1.
 
 0.900
purD
Phosphoribosylamine--glycine ligase; Belongs to the GARS family.
      
 0.817
CQD05294.1
Membrane protein.
      
 0.817
CQD16706.1
Citrate lyase beta chain citrase beta chain family protein; Belongs to the HpcH/HpaI aldolase family.
      
 0.817
CQD22731.1
Hypothetical protein.
      
 0.817
CQD12213.1
CitE protein; Belongs to the HpcH/HpaI aldolase family.
      
 0.782
Your Current Organism:
Mycobacterium europaeum
NCBI taxonomy Id: 761804
Other names: CCUG 58464, DSM 45397, M. europaeum, Mycobacterium europaeum Tortoli et al. 2011, Mycobacterium sp. DSM 45397, Mycobacterium sp. FI-06004, Mycobacterium sp. FI-09129, Mycobacterium sp. FI-09261, strain FI-95228
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