STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RR48_00577Ubiquitin carboxyl-terminal hydrolase 8. (199 aa)    
Predicted Functional Partners:
RR48_14887
E3 ubiquitin-protein ligase NRDP1.
    
 0.965
RR48_01761
Ubiquitin-40S ribosomal protein S27a.
    
 0.906
RR48_06406
Ubiquitin-60S ribosomal protein L40.
   
 0.878
RR48_01031
Signal transducing adapter molecule 1.
    
 0.861
RR48_11329
Ubiquitin thioesterase.
    
 0.717
RR48_10413
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
   
 0.671
RR48_10415
Hepatocyte growth factor-regulated tyrosine kinase substrate.
   
 0.671
RR48_10465
AN1-type zinc finger and ubiquitin domain-containing protein 1.
   
 0.620
RR48_08812
Non-specific serine/threonine protein kinase.
    
 0.613
RR48_06836
Ubiquitin-like protein 4A.
   
 0.611
Your Current Organism:
Papilio machaon
NCBI taxonomy Id: 76193
Other names: Old World swallowtail, P. machaon, artemisia swallowtail, common yellow swallowtail
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.