Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ivdisovaleryl-CoA dehydrogenase. (392 aa)    
Predicted Functional Partners:
ADP13474.1
Carboxyl transferase domain protein 1.
 
 
 0.985
ADP17817.1
enoyl-CoA hydratase/isomerase family protein 22.
  
 0.969
ADP13473.1
methylcrotonoyl-CoA carboxylase alpha subunit 1.
 
 0.950
fadB1
enoyl-CoA hydratase 1; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.942
bkdB
Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex.
   
 0.920
ADP18451.1
methylcrotonoyl-CoA carboxylase beta subunit.
 
 
 0.854
ADP13475.1
acetyl-CoA acetyltransferase family protein 1; Belongs to the thiolase-like superfamily. Thiolase family.
  
 0.814
aceK
Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
       0.781
ADP19208.1
Carboxyl transferase domain protein 2.
 
 
 0.731
ADP16970.1
enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase/3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.
  
 0.705
Your Current Organism:
Achromobacter xylosoxidans
NCBI taxonomy Id: 762376
Other names: A. xylosoxidans A8, Achromobacter xylosoxidans A8, Achromobacter xylosoxidans str. A8, Achromobacter xylosoxidans strain A8
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.