| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADP13397.1 | ADP14899.1 | AXYL_00035 | AXYL_01561 | L-allo-threonine aldolase. | Pyridoxal-phosphate dependent enzyme family protein 4. | 0.924 |
| ADP13397.1 | ADP16895.1 | AXYL_00035 | AXYL_03575 | L-allo-threonine aldolase. | Serine--glyoxylate aminotransferase. | 0.922 |
| ADP13397.1 | glyA1 | AXYL_00035 | AXYL_00671 | L-allo-threonine aldolase. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
| ADP13397.1 | glyA2 | AXYL_00035 | AXYL_05760 | L-allo-threonine aldolase. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.930 |
| ADP13397.1 | ilvA1 | AXYL_00035 | AXYL_03080 | L-allo-threonine aldolase. | Threonine dehydratase biosynthetic 1; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.911 |
| ADP13397.1 | ltaE | AXYL_00035 | AXYL_01582 | L-allo-threonine aldolase. | Low specificity L-threonine aldolase. | 0.913 |
| ADP13397.1 | thrC | AXYL_00035 | AXYL_01902 | L-allo-threonine aldolase. | Threonine synthase. | 0.924 |
| ADP14899.1 | ADP13397.1 | AXYL_01561 | AXYL_00035 | Pyridoxal-phosphate dependent enzyme family protein 4. | L-allo-threonine aldolase. | 0.924 |
| ADP14899.1 | ilvA1 | AXYL_01561 | AXYL_03080 | Pyridoxal-phosphate dependent enzyme family protein 4. | Threonine dehydratase biosynthetic 1; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.935 |
| ADP14899.1 | leuB2 | AXYL_01561 | AXYL_03894 | Pyridoxal-phosphate dependent enzyme family protein 4. | 3-isopropylmalate dehydrogenase 2. | 0.441 |
| ADP14899.1 | ltaE | AXYL_01561 | AXYL_01582 | Pyridoxal-phosphate dependent enzyme family protein 4. | Low specificity L-threonine aldolase. | 0.924 |
| ADP14899.1 | thrC | AXYL_01561 | AXYL_01902 | Pyridoxal-phosphate dependent enzyme family protein 4. | Threonine synthase. | 0.900 |
| ADP16895.1 | ADP13397.1 | AXYL_03575 | AXYL_00035 | Serine--glyoxylate aminotransferase. | L-allo-threonine aldolase. | 0.922 |
| ADP16895.1 | glyA1 | AXYL_03575 | AXYL_00671 | Serine--glyoxylate aminotransferase. | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
| ADP16895.1 | glyA2 | AXYL_03575 | AXYL_05760 | Serine--glyoxylate aminotransferase. | Serine hydroxymethyltransferase 2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.926 |
| ADP16895.1 | ilvA1 | AXYL_03575 | AXYL_03080 | Serine--glyoxylate aminotransferase. | Threonine dehydratase biosynthetic 1; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.912 |
| ADP16895.1 | ltaE | AXYL_03575 | AXYL_01582 | Serine--glyoxylate aminotransferase. | Low specificity L-threonine aldolase. | 0.922 |
| dsdA | ilvA1 | AXYL_01340 | AXYL_03080 | D-serine ammonia-lyase; Belongs to the serine/threonine dehydratase family. DsdA subfamily. | Threonine dehydratase biosynthetic 1; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.916 |
| glyA1 | ADP13397.1 | AXYL_00671 | AXYL_00035 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-allo-threonine aldolase. | 0.930 |
| glyA1 | ADP16895.1 | AXYL_00671 | AXYL_03575 | Serine hydroxymethyltransferase 1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine--glyoxylate aminotransferase. | 0.926 |
