STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pabAGlutamine amidotransferase, class I; COG: COG0512; Pfam: PF00117; InterPro: IPR006221. (210 aa)    
Predicted Functional Partners:
pabB
Aminodeoxychorismate synthase, component I; COG: COG0147; Pfam: PF04715,PF00425; InterPro: IPR005801.
 0.999
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
 0.999
trpD
Anthranilate phosphoribosyltransferase; COG: COG0547; Pfam: PF02885,PF00591; InterPro: IPR005940.
  
 0.997
trpC
Indole-3-glycerol phosphate synthase; COG: COG0134; Pfam: PF00218; InterPro: IPR013785.
  
 0.996
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
 
  
 0.949
dat
Aminotransferase, class IV; COG: COG0115; Pfam: PF01063; InterPro: IPR001544.
 
 
 0.929
trpB
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
 
  
 0.926
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
 
 0.875
tyrA
Chorismate mutase; COG: COG1605; Pfam: PF01817; InterPro: IPR010951.
  
 
 0.845
ADP40401.1
Hypothetical protein.
       0.773
Your Current Organism:
Rothia dentocariosa
NCBI taxonomy Id: 762948
Other names: R. dentocariosa ATCC 17931, Rothia dentocariosa ATCC 17931, Rothia dentocariosa str. ATCC 17931, Rothia dentocariosa strain ATCC 17931
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