STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (796 aa)    
Predicted Functional Partners:
EGF57001.1
KEGG: bcv:Bcav_0238 4.9e-49 methylenetetrahydrofolate reductase (NAD(P)H) K00297; Psort location: Cytoplasmic, score: 7.50.
 
 0.992
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.989
EGF50187.1
KEGG: sgo:SGO_1636 7.4e-101 cystathionine gamma-synthase K01739; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.969
EGF50031.1
KEGG: jde:Jden_2111 2.0e-153 O-acetylhomoserine/O-acetylserine sulfhydrylase K01740; Psort location: Cytoplasmic, score: 9.97.
  
 
 0.962
luxS
S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.953
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.932
EGF54376.1
KEGG: cfl:Cfla_1390 9.2e-103 cysteine synthase; K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 7.50; Belongs to the cysteine synthase/cystathionine beta- synthase family.
     
 0.928
EGF55937.1
KEGG: ske:Sked_09870 1.5e-125 homoserine dehydrogenase; K00003 homoserine dehydrogenase; Psort location: Cytoplasmic, score: 7.50.
   
 
 0.923
EGF52250.1
KEGG: lpl:lp_1298 2.8e-69 mmuM; homocysteine methyltransferase K00547.
   
 
 0.907
EGF52259.1
Aminotransferase, class I/II; KEGG: gob:Gobs_1786 8.8e-82 aminotransferase class I and II; K14155 cystathione beta-lyase; Psort location: Cytoplasmic, score: 7.50.
    
  0.874
Your Current Organism:
Actinomyces sp. F0386
NCBI taxonomy Id: 762963
Other names: A. sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 strain F0386
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.