STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (520 aa)    
Predicted Functional Partners:
guaA
GMP synthase domain protein; Catalyzes the synthesis of GMP from XMP.
 
 0.999
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.994
purH
KEGG: cfl:Cfla_2532 2.0e-187 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602; Psort location: Cytoplasmic, score: 7.50.
 
 
 0.985
EGF50276.1
Glutamine amidotransferase, class-I family protein; KEGG: aau:AAur_3417 5.1e-70 glutamine amidotransferase K01951.
  
 
 0.975
EGF50283.1
GMP synthase family protein; KEGG: ach:Achl_1315 8.7e-43 glutamine amidotransferase; K01951 GMP synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 7.50.
  
 
 0.975
EGF54091.1
KEGG: bcv:Bcav_0844 7.6e-28 glutamine amidotransferase class-I; K01951 GMP synthase (glutamine-hydrolysing); Psort location: Cytoplasmic, score: 7.50.
  
 
 0.973
ribBA
3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.959
EGF50037.1
KEGG: cfl:Cfla_0626 1.3e-73 hypoxanthine phosphoribosyltransferase K00760; Psort location: Cytoplasmic, score: 9.97; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
    
 0.958
pheT
phenylalanine--tRNA ligase, beta subunit; KEGG: mcu:HMPREF0573_10030 6.2e-255 pheT; phenylalanine--tRNA ligase K01890; Psort location: Cytoplasmic, score: 9.97; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
   
  
 0.955
EGF55230.1
KEGG: cfl:Cfla_2584 2.2e-147 IMP dehydrogenase family protein; K00088 IMP dehydrogenase; Psort location: Cytoplasmic, score: 7.50.
  
 
0.935
Your Current Organism:
Actinomyces sp. F0386
NCBI taxonomy Id: 762963
Other names: A. sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 strain F0386
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