STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EGF54334.1UvrD/REP helicase; KEGG: ske:Sked_27640 1.5e-173 DNA/RNA helicase, superfamily I; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97; overlaps another CDS with the same product name; Belongs to the helicase family. UvrD subfamily. (1146 aa)    
Predicted Functional Partners:
EGF54322.1
HRDC domain protein; KEGG: bcv:Bcav_2897 8.0e-223 UvrD/REP helicase; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97.
 
 
0.963
EGF54333.1
UvrD/REP helicase; KEGG: sen:SACE_1077 3.4e-96 ATP-dependent DNA helicase K01529; Psort location: Cytoplasmic, score: 7.50; overlaps another CDS with the same product name.
 
   
 0.933
EGF55948.1
KEGG: bcv:Bcav_3026 1.5e-259 ATP-dependent DNA helicase PcrA; K03657 DNA helicase II / ATP-dependent DNA helicase PcrA; Psort location: Cytoplasmic, score: 9.97.
  
  
0.915
EGF57174.1
KEGG: xce:Xcel_1305 2.8e-220 ATP-dependent DNA helicase, RecQ family; K03654 ATP-dependent DNA helicase RecQ; Psort location: Cytoplasmic, score: 9.97.
 
 0.748
EGF53716.1
GIY-YIG catalytic domain protein; KEGG: bcv:Bcav_1900 8.9e-121 hypothetical protein K02342; Psort location: Cytoplasmic, score: 9.97.
 
 
 0.733
EGF56765.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.707
recA
RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.684
EGF57035.1
Hypothetical protein; KEGG: aai:AARI_11550 9.7e-131 putative ATP-dependent DNA helicase; Psort location: CytoplasmicMembrane, score: 8.16.
  
  
 0.675
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
   
 
 0.641
EGF54332.1
Hypothetical protein; KEGG: ppw:PputW619_1440 0.0048 oxidase; K08967 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Psort location: Cytoplasmic, score: 7.50.
 
     0.631
Your Current Organism:
Actinomyces sp. F0386
NCBI taxonomy Id: 762963
Other names: A. sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 strain F0386
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.