STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (215 aa)    
Predicted Functional Partners:
nadE
NAD(+) synthase domain protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.991
EGF52234.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
 
 
 0.980
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
 0.931
EGF51809.1
Competence/damage-inducible protein CinA domain protein; KEGG: rsp:RSP_1822 7.5e-13 NH(3)-dependent NAD(+) synthetase K03743; Belongs to the CinA family.
  
 
 0.917
rsfS
Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.915
EGF54321.1
Hydrolase, NUDIX family; KEGG: cfl:Cfla_2471 1.2e-59 NAD(+) diphosphatase K03426; Psort location: Cytoplasmic, score: 7.50.
     
 0.884
EGF54330.1
KEGG: ere:EUBREC_3268 7.6e-60 NAD-dependent deacetylase; K12410 NAD-dependent deacetylase; Psort location: Cytoplasmic, score: 7.50.
    
 0.859
EGF53827.1
Conserved domain protein; KEGG: sce:YIR019C 4.6e-10 MUC1, FLO11, STA4; GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); K01178 glucoamylase.
       0.778
EGF55271.1
Hypothetical protein; KEGG: hit:NTHI1634 2.1e-08 NAD-dependent deacetylase sirtuin 5 K01463.
    
 0.749
EGF53470.1
KEGG: bcv:Bcav_2017 9.1e-64 shikimate dehydrogenase substrate binding domain protein; K00014 shikimate dehydrogenase; Belongs to the shikimate dehydrogenase family.
  
  
 0.738
Your Current Organism:
Actinomyces sp. F0386
NCBI taxonomy Id: 762963
Other names: A. sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 str. F0386, Actinomyces sp. oral taxon 170 strain F0386
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.