EHG99810.1 protein (Paraprevotella clara) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

EHG99810.1

Hypothetical protein; Psort location: Cytoplasmic, score: 8.96. (264 aa)

Predicted Functional Partners:

EHG99811.1

0.791

EHG99808.1

0.790

EHG99809.1

0.777

EHG99806.1

0.773

EHG99807.1

0.773

EHG99812.1

0.718

EHG99813.1

0.718

EHG99815.1

0.680

EHG99814.1

0.508

Your Current Organism:

Paraprevotella clara

NCBI taxonomy Id: 762968
Other names: P. clara YIT 11840, Paraprevotella clara YIT 11840, Paraprevotella clara str. YIT 11840, Paraprevotella clara strain YIT 11840

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EHG99806.1	EHG99807.1	HMPREF9441_02238	HMPREF9441_02239	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein.	0.773
EHG99806.1	EHG99808.1	HMPREF9441_02238	HMPREF9441_02240	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.773
EHG99806.1	EHG99809.1	HMPREF9441_02238	HMPREF9441_02241	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein.	0.773
EHG99806.1	EHG99810.1	HMPREF9441_02238	HMPREF9441_02242	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.773
EHG99806.1	EHG99811.1	HMPREF9441_02238	HMPREF9441_02243	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Putative phage nucleotide-binding protein.	0.773
EHG99806.1	EHG99812.1	HMPREF9441_02238	HMPREF9441_02244	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein.	0.718
EHG99806.1	EHG99813.1	HMPREF9441_02238	HMPREF9441_02245	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.718
EHG99806.1	EHG99814.1	HMPREF9441_02238	HMPREF9441_02246	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82.	0.508
EHG99806.1	EHG99815.1	HMPREF9441_02238	HMPREF9441_02247	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein.	0.680
EHG99807.1	EHG99806.1	HMPREF9441_02239	HMPREF9441_02238	Hypothetical protein.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.773
EHG99807.1	EHG99808.1	HMPREF9441_02239	HMPREF9441_02240	Hypothetical protein.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.773
EHG99807.1	EHG99809.1	HMPREF9441_02239	HMPREF9441_02241	Hypothetical protein.	Hypothetical protein.	0.773
EHG99807.1	EHG99810.1	HMPREF9441_02239	HMPREF9441_02242	Hypothetical protein.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.773
EHG99807.1	EHG99811.1	HMPREF9441_02239	HMPREF9441_02243	Hypothetical protein.	Putative phage nucleotide-binding protein.	0.773
EHG99807.1	EHG99812.1	HMPREF9441_02239	HMPREF9441_02244	Hypothetical protein.	Hypothetical protein.	0.718
EHG99807.1	EHG99813.1	HMPREF9441_02239	HMPREF9441_02245	Hypothetical protein.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.718
EHG99807.1	EHG99814.1	HMPREF9441_02239	HMPREF9441_02246	Hypothetical protein.	Hypothetical protein; Psort location: CytoplasmicMembrane, score: 9.82.	0.508
EHG99807.1	EHG99815.1	HMPREF9441_02239	HMPREF9441_02247	Hypothetical protein.	Hypothetical protein.	0.680
EHG99808.1	EHG99806.1	HMPREF9441_02240	HMPREF9441_02238	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	0.773
EHG99808.1	EHG99807.1	HMPREF9441_02240	HMPREF9441_02239	Hypothetical protein; Psort location: Cytoplasmic, score: 8.96.	Hypothetical protein.	0.773

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.91

expected number of edges:

11

PPI enrichment p-value:

4.18e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 5

2.73

3.42

4.23e-07

GO:0006289

Nucleotide-excision repair

3 of 11

2.26

1.98

0.00016

GO:0009432

SOS response

3 of 19

2.02

1.66

0.00052

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009381

Excinuclease ABC activity

3 of 10

2.3

1.76

0.00048

GO:0008965

Phosphoenolpyruvate-protein phosphotransferase activity

2 of 2

2.82

1.53

0.0017

GO:0004518

Nuclease activity

4 of 61

1.64

1.48

0.00048

GO:0016887

ATP hydrolysis activity

3 of 61

1.52

0.94

0.0096

GO:0140640

Catalytic activity, acting on a nucleic acid

4 of 245

1.04

0.6

0.0266

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009380

Excinuclease repair complex

3 of 10

2.3

2.11

9.25e-05

GO:0005737

Cytoplasm

8 of 1249

0.63

0.49

0.0024

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:18485189

(2008) Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context.

5 of 6

2.74

5.21

1.31e-10

PMID:26257709

(2015) The reduced genomes of Parcubacteria (OD1) contain signatures of a symbiotic lifestyle.

3 of 24

1.92

1.68

0.00039

PMID:15886391

(2005) An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus.

2 of 5

2.43

1.51

0.0016

PMID:23902135

(2013) GTAG- and CGTC-tagged palindromic DNA repeats in prokaryotes.

2 of 6

2.35

1.5

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9636

Mixed, incl. Import across plasma membrane, and Mannoside phosphorylase

5 of 17

2.29

3.7

3.41e-08

CL:9655

Import across plasma membrane, and Type I phosphodiesterase / nucleotide pyrophosphatase

4 of 6

2.65

3.6

1.72e-07

CL:9634

Mostly uncharacterized, incl. Import across plasma membrane, and Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

6 of 39

2.01

3.41

2.56e-08

CL:915

DNA excision

3 of 6

2.52

2.29

5.26e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rba02060

Phosphotransferase system (PTS)

4 of 5

2.73

3.97

3.71e-08

rba03420

Nucleotide excision repair

3 of 12

2.22

2.17

6.10e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009380

Excinuclease repair complex

3 of 10

2.3

1.97

0.00018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0267

Excision nuclease

3 of 5

2.6

2.43

3.02e-05

KW-0228

DNA excision

3 of 5

2.6

2.43

3.02e-05

KW-0598

Phosphotransferase system

2 of 2

2.82

1.83

0.00046

KW-0762

Sugar transport

2 of 3

2.65

1.75

0.00063

KW-0670

Pyruvate

2 of 13

2.01

1.17

0.0057

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05524

PEP-utilising enzyme, N-terminal

2 of 2

2.82

1.16

0.0079

PF02896

PEP-utilising enzyme, PEP-binding domain

2 of 3

2.65

1.16

0.0079

PF00391

PEP-utilising enzyme, mobile domain

2 of 3

2.65

1.16

0.0079

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041102

UvrA, interaction domain

2 of 3

2.65

0.95

0.0192

IPR036637

Phosphohistidine domain superfamily

2 of 3

2.65

0.95

0.0192

IPR036618

PtsI, HPr-binding domain superfamily

2 of 2

2.82

0.95

0.0192

IPR024692

Phosphotransferase system, enzyme I

2 of 2

2.82

0.95

0.0192

IPR023151

PEP-utilising enzyme, conserved site

2 of 3

2.65

0.95

0.0192

(more ...)

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