Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
metF-25,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (305 aa)    
Predicted Functional Partners:
gcvT2
Glycine cleavage system T protein.
  
 
 0.997
bmt
Homocysteine S-methyltransferase family protein.
 
 
 0.994
metH4
Pterin binding enzyme family protein.
 
 
 0.992
glyA1
Serine hydroxymethyltransferase family protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.987
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.967
MCHK_0821
Aminomethyltransferase folate-binding domain protein; Belongs to the GcvT family.
  
 
 0.957
folD1
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.951
folD2
Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.951
MCHK_5051
Aminomethyltransferase folate-binding domain protein; Belongs to the GcvT family.
  
 
 0.951
MCHK_0600
FAD dependent oxidoreductase family protein; Belongs to the GcvT family.
  
 
 0.946
Your Current Organism:
Mesorhizobium huakuii
NCBI taxonomy Id: 763057
Other names: M. huakuii 7653R, Mesorhizobium huakuii 7653R, Mesorhizobium huakuii str. 7653R, Mesorhizobium huakuii strain 7653R
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