A0A162TFA2 protein (Phycomyces blakesleeanus)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

A0A162TFA2

PlsC domain-containing protein. (806 aa)

Predicted Functional Partners:

A0A162ZQ39

0.889

A0A162TXG3

0.865

A0A162ZCB5

0.863

A0A162TI29

0.827

A0A162WX02

0.827

Ndufab1

0.822

NDUFAB1_2

0.822

NDUFAB1

0.822

A0A167LUR5

0.819

A0A167M8I5

0.811

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162TFA2	A0A162TI29	A0A162TFA2	A0A162TI29	PlsC domain-containing protein.	PlsC domain-containing protein.	0.827
A0A162TFA2	A0A162TXG3	A0A162TFA2	A0A162TXG3	PlsC domain-containing protein.	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.865
A0A162TFA2	A0A162WX02	A0A162TFA2	A0A162WX02	PlsC domain-containing protein.	PlsC domain-containing protein.	0.827
A0A162TFA2	A0A162ZCB5	A0A162TFA2	A0A162ZCB5	PlsC domain-containing protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.863
A0A162TFA2	A0A162ZQ39	A0A162TFA2	A0A162ZQ39	PlsC domain-containing protein.	Uncharacterized protein.	0.889
A0A162TFA2	A0A167LUR5	A0A162TFA2	A0A167LUR5	PlsC domain-containing protein.	LNS2 domain-containing protein.	0.819
A0A162TFA2	A0A167M8I5	A0A162TFA2	A0A167M8I5	PlsC domain-containing protein.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.811
A0A162TFA2	NDUFAB1	A0A162TFA2	A0A162YKT8	PlsC domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.822
A0A162TFA2	NDUFAB1_2	A0A162TFA2	A0A162TCT3	PlsC domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.822
A0A162TFA2	Ndufab1	A0A162TFA2	A0A162N3V8	PlsC domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.822
A0A162TI29	A0A162TFA2	A0A162TI29	A0A162TFA2	PlsC domain-containing protein.	PlsC domain-containing protein.	0.827
A0A162TI29	A0A162TXG3	A0A162TI29	A0A162TXG3	PlsC domain-containing protein.	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	0.810
A0A162TI29	A0A162ZCB5	A0A162TI29	A0A162ZCB5	PlsC domain-containing protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.838
A0A162TI29	A0A162ZQ39	A0A162TI29	A0A162ZQ39	PlsC domain-containing protein.	Uncharacterized protein.	0.496
A0A162TI29	A0A167LUR5	A0A162TI29	A0A167LUR5	PlsC domain-containing protein.	LNS2 domain-containing protein.	0.813
A0A162TI29	A0A167M8I5	A0A162TI29	A0A167M8I5	PlsC domain-containing protein.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.660
A0A162TI29	NDUFAB1	A0A162TI29	A0A162YKT8	PlsC domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.668
A0A162TI29	NDUFAB1_2	A0A162TI29	A0A162TCT3	PlsC domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.668
A0A162TI29	Ndufab1	A0A162TI29	A0A162N3V8	PlsC domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.668
A0A162TXG3	A0A162TFA2	A0A162TXG3	A0A162TFA2	Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.	PlsC domain-containing protein.	0.865

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Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.844

expected number of edges:

5

PPI enrichment p-value:

0.0728

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006614

SRP-dependent cotranslational protein targeting to membrane

7 of 11

2.81

7.56

2.89e-15

GO:0045047

Protein targeting to ER

8 of 27

2.48

7.05

2.29e-15

GO:0006616

SRP-dependent cotranslational protein targeting to membrane, translocation

2 of 4

2.71

1.51

0.0018

GO:0000027

Ribosomal large subunit assembly

2 of 20

2.01

0.84

0.0256

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008312

7S RNA binding

5 of 6

2.93

5.18

2.33e-10

GO:0005047

Signal recognition particle binding

3 of 3

3.01

2.72

1.12e-05

GO:0043021

Ribonucleoprotein complex binding

4 of 45

1.95

2.06

5.56e-05

GO:0005048

Signal sequence binding

3 of 18

2.23

1.84

0.00030

GO:0030942

Endoplasmic reticulum signal peptide binding

2 of 3

2.83

1.51

0.0018

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005786

Signal recognition particle, endoplasmic reticulum targeting

5 of 6

2.93

5.33

1.22e-10

GO:0030867

Rough endoplasmic reticulum membrane

3 of 10

2.48

2.38

3.37e-05

GO:0005785

Signal recognition particle receptor complex

2 of 2

3.01

1.77

0.00063

GO:1990904

Ribonucleoprotein complex

8 of 444

1.26

1.68

2.79e-07

GO:0140534

Endoplasmic reticulum protein-containing complex

3 of 71

1.63

1.11

0.0046

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7281

7S RNA binding

5 of 6

2.93

5.14

2.86e-10

CL:6958

Cap-dependent Translation Initiation, and Translation elongation factor activity

8 of 169

1.68

3.17

5.23e-10

CL:7323

Organellar large ribosomal subunit, and Ribosomal protein S9

3 of 26

2.07

1.43

0.0017

CL:7325

Organellar large ribosomal subunit, and Ribosomal protein S9

2 of 21

1.98

0.75

0.0389

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03060

Protein export

8 of 35

2.37

6.99

6.07e-16

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

10 of 127

1.9

5.23

5.67e-16

MAP-72766

Translation

11 of 272

1.61

3.8

1.07e-15

MAP-392499

Metabolism of proteins

11 of 987

1.05

1.39

8.65e-10

MAP-381070

IRE1alpha activates chaperones

2 of 18

2.05

0.76

0.0390

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0048500

Signal recognition particle

5 of 17

2.47

4.14

8.24e-09

GOCC:0005786

Signal recognition particle, endoplasmic reticulum targeting

4 of 16

2.4

3.15

8.06e-07

GOCC:0030867

Rough endoplasmic reticulum membrane

3 of 14

2.34

2.12

9.47e-05

GOCC:1990904

Ribonucleoprotein complex

8 of 438

1.27

1.67

4.46e-07

GOCC:0005785

Signal recognition particle receptor complex

2 of 6

2.53

1.37

0.0030

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0733

Signal recognition particle

3 of 3

3.01

3.0

3.44e-06

KW-0963

Cytoplasm

3 of 151

1.3

0.67

0.0316

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042101

Signal recognition particle SRP54, N-terminal domain superfamily

2 of 2

3.01

1.01

0.0154

IPR036225

SRP/SRP receptor, N-terminal

2 of 2

3.01

1.01

0.0154

IPR013822

Signal recognition particle SRP54, helical bundle

2 of 2

3.01

1.01

0.0154

IPR000897

Signal recognition particle, SRP54 subunit, GTPase domain

2 of 3

2.83

1.0

0.0154

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00963

SRP54-type protein, helical bundle domain

2 of 2

3.01

1.52

0.0018

SM00962

SRP54-type protein, GTPase domain

2 of 2

3.01

1.52

0.0018

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