A0A162TIY6 protein (Phycomyces blakesleeanus)

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A162TIY6

Uncharacterized protein. (1294 aa)

Predicted Functional Partners:

A0A162UTR4

0.740

A0A167Q0J1

0.718

A0A162ULV7

0.671

A0A167JAU8

0.661

A0A162V9Q6

0.645

A0A162Q5N3

0.637

A0A167MLT6

0.623

QCR2

0.616

A0A162NGA9

0.613

A0A162UBD0

0.601

Your Current Organism:

Phycomyces blakesleeanus

NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A162NGA9	A0A162TIY6	A0A162NGA9	A0A162TIY6	AAA domain-containing protein; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.613
A0A162NGA9	A0A162UBD0	A0A162NGA9	A0A162UBD0	AAA domain-containing protein; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.999
A0A162Q5N3	A0A162TIY6	A0A162Q5N3	A0A162TIY6	RING-type domain-containing protein.	Uncharacterized protein.	0.637
A0A162TIY6	A0A162NGA9	A0A162TIY6	A0A162NGA9	Uncharacterized protein.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.613
A0A162TIY6	A0A162Q5N3	A0A162TIY6	A0A162Q5N3	Uncharacterized protein.	RING-type domain-containing protein.	0.637
A0A162TIY6	A0A162UBD0	A0A162TIY6	A0A162UBD0	Uncharacterized protein.	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	0.601
A0A162TIY6	A0A162ULV7	A0A162TIY6	A0A162ULV7	Uncharacterized protein.	RGS domain-containing protein.	0.671
A0A162TIY6	A0A162UTR4	A0A162TIY6	A0A162UTR4	Uncharacterized protein.	Uncharacterized protein.	0.740
A0A162TIY6	A0A162V9Q6	A0A162TIY6	A0A162V9Q6	Uncharacterized protein.	IP3 receptor.	0.645
A0A162TIY6	A0A167JAU8	A0A162TIY6	A0A167JAU8	Uncharacterized protein.	Uncharacterized protein.	0.661
A0A162TIY6	A0A167MLT6	A0A162TIY6	A0A167MLT6	Uncharacterized protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.623
A0A162TIY6	A0A167Q0J1	A0A162TIY6	A0A167Q0J1	Uncharacterized protein.	Uncharacterized protein.	0.718
A0A162TIY6	QCR2	A0A162TIY6	A0A162PPF8	Uncharacterized protein.	Ubiquinol-cytochrome c reductase core subunit 1.	0.616
A0A162UBD0	A0A162NGA9	A0A162UBD0	A0A162NGA9	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	AAA domain-containing protein; Belongs to the AAA ATPase family.	0.999
A0A162UBD0	A0A162TIY6	A0A162UBD0	A0A162TIY6	26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.	Uncharacterized protein.	0.601
A0A162ULV7	A0A162TIY6	A0A162ULV7	A0A162TIY6	RGS domain-containing protein.	Uncharacterized protein.	0.671
A0A162ULV7	A0A167MLT6	A0A162ULV7	A0A167MLT6	RGS domain-containing protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.668
A0A162UTR4	A0A162TIY6	A0A162UTR4	A0A162TIY6	Uncharacterized protein.	Uncharacterized protein.	0.740
A0A162UTR4	QCR2	A0A162UTR4	A0A162PPF8	Uncharacterized protein.	Ubiquinol-cytochrome c reductase core subunit 1.	0.647
A0A162V9Q6	A0A162TIY6	A0A162V9Q6	A0A162TIY6	IP3 receptor.	Uncharacterized protein.	0.645

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

11

PPI enrichment p-value:

0.000151

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1905515

Non-motile cilium assembly

3 of 28

2.32

1.81

0.00039

GO:0060271

Cilium assembly

5 of 196

1.7

1.69

0.00016

GO:0035973

Aggrephagy

2 of 5

2.89

1.49

0.0020

GO:0000423

Mitophagy

2 of 7

2.74

1.39

0.0030

GO:0016050

Vesicle organization

3 of 100

1.77

1.13

0.0053

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070530

K63-linked polyubiquitin modification-dependent protein binding

2 of 12

2.51

0.78

0.0389

GO:0005080

Protein kinase C binding

2 of 12

2.51

0.78

0.0389

GO:0005515

Protein binding

8 of 3064

0.71

0.41

0.0389

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034464

BBSome

4 of 6

3.11

4.43

7.94e-09

GO:0060170

Ciliary membrane

3 of 18

2.51

2.39

3.35e-05

GO:0005813

Centrosome

5 of 205

1.68

2.04

1.28e-05

GO:0005815

Microtubule organizing center

6 of 333

1.54

2.02

3.28e-06

GO:0044753

Amphisome

2 of 3

3.11

1.92

0.00034

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15359

BBSome

5 of 6

3.21

6.09

7.07e-12

CL:15347

Mixed, incl. BBSome, and Genitalia morphogenesis

6 of 23

2.7

5.88

5.00e-12

CL:14124

Mixed, incl. Amphisome, and AhpD-like

2 of 6

2.81

1.54

0.0016

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5620920

Cargo trafficking to the periciliary membrane

5 of 56

2.24

3.46

9.39e-08

MAP-9755511

KEAP1-NFE2L2 pathway

5 of 60

2.21

3.43

9.39e-08

MAP-9711123

Cellular response to chemical stress

5 of 117

1.92

2.7

1.07e-06

MAP-5617833

Cilium Assembly

5 of 206

1.67

2.04

1.27e-05

MAP-1852241

Organelle biogenesis and maintenance

5 of 236

1.61

1.91

1.97e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034464

BBSome

4 of 5

3.19

4.54

5.34e-09

GOCC:0005929

Cilium

5 of 269

1.56

1.67

8.09e-05

GOCC:0005776

Autophagosome

2 of 26

2.17

0.91

0.0202

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045093

Cullin

2 of 5

2.89

1.01

0.0149

IPR036317

Cullin homology domain superfamily

2 of 6

2.81

1.01

0.0149

IPR019559

Cullin protein, neddylation domain

2 of 4

2.99

1.01

0.0149

IPR016158

Cullin homology domain

2 of 5

2.89

1.01

0.0149

IPR001373

Cullin, N-terminal

2 of 6

2.81

1.01

0.0149

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00884

Cullin protein neddylation domain

2 of 4

2.99

1.48

0.0021

SM00182

Cullin

2 of 5

2.89

1.48

0.0021

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