STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A167PY74ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (632 aa)    
Predicted Functional Partners:
A0A167L9A7
Uncharacterized protein.
   
 0.999
A0A162V3B0
Uncharacterized protein.
  
 0.985
A0A167NFT6
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
  
 0.984
A0A167L178
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
   
 0.980
A0A163APY4
Uncharacterized protein.
  
 0.975
A0A163DCB2
PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.
   
 0.975
A0A163B0P3
ERCC4 domain-containing protein.
   
 0.973
A0A162NDE4
Uncharacterized protein.
   
 0.972
A0A162T215
Mre11_DNA_bind domain-containing protein; Belongs to the MRE11/RAD32 family.
  
 0.972
A0A162PIM8
Uncharacterized protein.
   
 0.971
Your Current Organism:
Phycomyces blakesleeanus
NCBI taxonomy Id: 763407
Other names: P. blakesleeanus NRRL 1555(-), Phycomyces blakesleeanus NRRL 1555(-)
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.