STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mo02769Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (189 aa)    
Predicted Functional Partners:
Mo01919
Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.
   
 0.967
Mo01240
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.
  
 0.963
Mo06506
Uncharacterized protein.
  
 
 0.953
Mo04973
dUTPase domain-containing protein.
  
 0.951
Mo00348
Guanylate kinase-like domain-containing protein.
  
 
 0.946
Mo00816
Uncharacterized protein; Belongs to the NDK family.
  
 0.940
Mo05871
A_deaminase domain-containing protein.
    
 0.939
Mo03352
Pribosyltran domain-containing protein.
  
 0.937
Mo05862
Pyruvate kinase; Belongs to the pyruvate kinase family.
    
 0.927
Mo02311
GTP_cyclohydroI domain-containing protein.
  
 
 0.914
Your Current Organism:
Mixia osmundae
NCBI taxonomy Id: 764103
Other names: M. osmundae IAM 14324, Mixia osmundae IAM 14324
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