Mo05606 protein (Mixia osmundae) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Mo05606

Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (276 aa)

Predicted Functional Partners:

Mo02445

0.980

Mo03676

0.976

Mo02580

0.931

Mo05419

0.912

Mo06730

0.912

Mo06729

0.912

Mo06168

0.907

Mo05530

0.889

Mo02979

0.837

Mo04222

0.833

Your Current Organism:

Mixia osmundae

NCBI taxonomy Id: 764103
Other names: M. osmundae IAM 14324, Mixia osmundae IAM 14324

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Mo02445	Mo02580	G7DYX8	G7DZB2	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.871
Mo02445	Mo02979	G7DYX8	G7E0F3	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	TIP120 domain-containing protein.	0.833
Mo02445	Mo03676	G7DYX8	G7E2E2	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	RING-type domain-containing protein.	0.980
Mo02445	Mo04222	G7DYX8	G7E3Y4	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	MPN domain-containing protein.	0.674
Mo02445	Mo05419	G7DYX8	G7E7C1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Cullin domain-containing protein; Belongs to the cullin family.	0.838
Mo02445	Mo05530	G7DYX8	G7E7N2	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.844
Mo02445	Mo05606	G7DYX8	G7E7V8	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.	0.980
Mo02445	Mo06168	G7DYX8	G7EA00	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-like domain-containing protein.	0.990
Mo02445	Mo06729	G7DYX8	G7EB17	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.838
Mo02445	Mo06730	G7DYX8	G7EB16	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.838
Mo02580	Mo02445	G7DZB2	G7DYX8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.871
Mo02580	Mo02979	G7DZB2	G7E0F3	CULLIN_2 domain-containing protein; Belongs to the cullin family.	TIP120 domain-containing protein.	0.908
Mo02580	Mo03676	G7DZB2	G7E2E2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	RING-type domain-containing protein.	0.946
Mo02580	Mo04222	G7DZB2	G7E3Y4	CULLIN_2 domain-containing protein; Belongs to the cullin family.	MPN domain-containing protein.	0.920
Mo02580	Mo05530	G7DZB2	G7E7N2	CULLIN_2 domain-containing protein; Belongs to the cullin family.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.570
Mo02580	Mo05606	G7DZB2	G7E7V8	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.	0.931
Mo02580	Mo06168	G7DZB2	G7EA00	CULLIN_2 domain-containing protein; Belongs to the cullin family.	Ubiquitin-like domain-containing protein.	0.909
Mo02979	Mo02445	G7E0F3	G7DYX8	TIP120 domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.833
Mo02979	Mo02580	G7E0F3	G7DZB2	TIP120 domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.908
Mo02979	Mo03676	G7E0F3	G7E2E2	TIP120 domain-containing protein.	RING-type domain-containing protein.	0.973

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

12

PPI enrichment p-value:

0.000746

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 354

1.79

4.36

4.84e-14

GO:0002183

Cytoplasmic translational initiation

3 of 27

2.39

2.12

0.00010

GO:0006446

Regulation of translational initiation

3 of 52

2.1

1.67

0.00057

GO:0075522

IRES-dependent viral translational initiation

2 of 5

2.94

1.61

0.0012

GO:0001732

Formation of cytoplasmic translation initiation complex

2 of 19

2.36

1.09

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

7 of 53

2.46

6.09

3.62e-13

GO:0043022

Ribosome binding

3 of 72

1.96

1.33

0.0025

GO:0031369

Translation initiation factor binding

2 of 20

2.34

1.02

0.0130

GO:0003735

Structural constituent of ribosome

3 of 176

1.57

0.85

0.0170

GO:0003723

RNA binding

6 of 1158

1.05

0.83

0.0025

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005850

Eukaryotic translation initiation factor 2 complex

3 of 3

3.34

3.19

1.75e-06

GO:0033290

Eukaryotic 48S preinitiation complex

3 of 16

2.61

2.45

2.82e-05

GO:0005840

Ribosome

5 of 203

1.73

2.11

1.25e-05

GO:0015935

Small ribosomal subunit

3 of 49

2.13

1.8

0.00032

GO:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

2 of 6

2.86

1.67

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18379

Eukaryotic 43S preinitiation complex, and Eukaryotic translation initiation factor 2 complex

4 of 23

2.58

3.09

1.53e-06

CL:18383

Eukaryotic translation initiation factor 3 complex

3 of 11

2.78

2.85

5.49e-06

CL:18365

Translational initiation, and Negative regulation of translational initiation

5 of 86

2.1

2.82

1.53e-06

CL:17695

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 102

2.03

2.76

1.53e-06

CL:17712

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 43

2.18

1.89

0.00022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

7 of 283

1.73

3.17

2.11e-09

map03010

Ribosome

3 of 198

1.52

0.95

0.0088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

7 of 64

2.38

5.95

3.31e-13

MAP-72649

Translation initiation complex formation

7 of 70

2.34

5.87

3.31e-13

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

7 of 74

2.32

5.81

3.38e-13

MAP-72702

Ribosomal scanning and start codon recognition

7 of 77

2.3

5.76

3.77e-13

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 129

2.13

5.4

2.41e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005850

Eukaryotic translation initiation factor 2 complex

3 of 8

2.91

2.6

1.80e-05

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

2 of 15

2.47

0.93

0.0198

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 24

2.26

0.88

0.0236

GOCC:0005840

Ribosome

3 of 150

1.64

0.84

0.0205

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 55

2.38

5.1

3.48e-11

KW-0689

Ribosomal protein

3 of 165

1.6

1.03

0.0065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08662

Eukaryotic translation initiation factor eIF2A

3 of 3

3.34

3.03

3.31e-06

PF03144

Elongation factor Tu domain 2

2 of 15

2.47

0.83

0.0301

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