| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHJ52454.1 | coaC | STRMA_0537 | STRMA_0667 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Phosphopantothenoylcysteine decarboxylase. | 0.485 |
| EHJ52454.1 | fhs | STRMA_0537 | STRMA_0665 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.979 |
| EHJ52454.1 | fmt | STRMA_0537 | STRMA_0072 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.641 |
| EHJ52454.1 | folA | STRMA_0537 | STRMA_0587 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.931 |
| EHJ52454.1 | folD | STRMA_0537 | STRMA_1148 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.977 |
| EHJ52454.1 | glyA | STRMA_0537 | STRMA_0674 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
| EHJ52454.1 | metE | STRMA_0537 | STRMA_0536 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.999 |
| EHJ52454.1 | purH | STRMA_0537 | STRMA_1661 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.937 |
| EHJ52454.1 | purN | STRMA_0537 | STRMA_1659 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.934 |
| EHJ52998.1 | fhs | STRMA_1655 | STRMA_0665 | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.863 |
| EHJ52998.1 | fmt | STRMA_1655 | STRMA_0072 | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.891 |
| EHJ52998.1 | folD | STRMA_1655 | STRMA_1148 | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.915 |
| EHJ52998.1 | glyA | STRMA_1655 | STRMA_0674 | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.975 |
| EHJ52998.1 | purH | STRMA_1655 | STRMA_1661 | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.999 |
| EHJ52998.1 | purN | STRMA_1655 | STRMA_1659 | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
| coaC | EHJ52454.1 | STRMA_0667 | STRMA_0537 | Phosphopantothenoylcysteine decarboxylase. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.485 |
| coaC | fhs | STRMA_0667 | STRMA_0665 | Phosphopantothenoylcysteine decarboxylase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.840 |
| fhs | EHJ52454.1 | STRMA_0665 | STRMA_0537 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.979 |
| fhs | EHJ52998.1 | STRMA_0665 | STRMA_1655 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylformylglycinamidine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | 0.863 |
| fhs | coaC | STRMA_0665 | STRMA_0667 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphopantothenoylcysteine decarboxylase. | 0.840 |
