Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EHJ52751.1HAD hydrolase, TIGR01457 family; Catalyzes the dephosphorylation of 2-6 carbon acid sugars in vitro; Belongs to the HAD-like hydrolase superfamily. NagD family. (257 aa)    
Predicted Functional Partners:
EHJ52032.1
TIGR01906 family protein.
  
    0.918
EHJ51636.1
Hydrolase of X-linked nucleoside pyrophosphate N-terminal domain protein.
    
  0.896
EHJ52132.1
acyl-ACP thioesterase.
       0.828
EHJ53186.1
Putative coproporphyrinogen dehydrogenase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.
       0.828
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.771
cinA
Competence/damage-inducible protein CinA; Belongs to the CinA family.
   
 
  0.760
guaA
GMP synthase (glutamine-hydrolyzing), C-terminal domain protein; Catalyzes the synthesis of GMP from XMP.
    
  0.740
cmk
Cytidylate kinase.
  
 
  0.730
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase.
    
  0.710
EHJ53163.1
Hypothetical protein.
 
  
 0.689
Your Current Organism:
Streptococcus macacae
NCBI taxonomy Id: 764298
Other names: S. macacae NCTC 11558, Streptococcus macacae ATCC 35911, Streptococcus macacae CCUG 27653, Streptococcus macacae CIP 102912, Streptococcus macacae LMG 15097, Streptococcus macacae NCTC 11558, Streptococcus macacae str. NCTC 11558, Streptococcus macacae strain NCTC 11558
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.