Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
lacAGalactose-6-phosphate isomerase, LacA subunit. (142 aa)    
Predicted Functional Partners:
lacB
Galactose-6-phosphate isomerase, LacB subunit.
 
0.999
pfkB
1-phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
 
 0.929
lacG
6-phospho-beta-galactosidase; Belongs to the glycosyl hydrolase 1 family.
 
 
 0.928
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
 
 0.915
lacD
Tagatose-bisphosphate aldolase; Belongs to the aldolase LacD family.
 
  
 0.895
EHJ53339.1
PTS system, lactose-specific IIC component.
 
  
 0.877
gmuD
6-phospho-beta-glucosidase GmuD; Belongs to the glycosyl hydrolase 1 family.
  
 
 0.721
EHJ52454.1
Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein.
    
  0.704
EHJ52550.1
Transcriptional regulator, DeoR family.
 
  
 0.691
rpiA
Ribose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
     
 0.690
Your Current Organism:
Streptococcus macacae
NCBI taxonomy Id: 764298
Other names: S. macacae NCTC 11558, Streptococcus macacae ATCC 35911, Streptococcus macacae CCUG 27653, Streptococcus macacae CIP 102912, Streptococcus macacae LMG 15097, Streptococcus macacae NCTC 11558, Streptococcus macacae str. NCTC 11558, Streptococcus macacae strain NCTC 11558
Server load: low (32%) [HD]