| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EHI68894.1 | EHI69449.1 | STRIC_1699 | STRIC_1217 | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.954 |
| EHI68894.1 | fhs_1 | STRIC_1699 | STRIC_1157 | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.517 |
| EHI68894.1 | glyA | STRIC_1699 | STRIC_1300 | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.673 |
| EHI68894.1 | luxS | STRIC_1699 | STRIC_1674 | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.943 |
| EHI68894.1 | metE | STRIC_1699 | STRIC_1216 | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.931 |
| EHI68894.1 | metK | STRIC_1699 | STRIC_0510 | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.623 |
| EHI69449.1 | EHI68894.1 | STRIC_1217 | STRIC_1699 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Putative cysteine synthase; An automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift. | 0.954 |
| EHI69449.1 | EHI69502.1 | STRIC_1217 | STRIC_1153 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Glycine cleavage H-protein. | 0.957 |
| EHI69449.1 | EHI69941.1 | STRIC_1217 | STRIC_2414 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Methionine adenosyltransferase, N-terminal domain protein. | 0.958 |
| EHI69449.1 | fhs_1 | STRIC_1217 | STRIC_1157 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.948 |
| EHI69449.1 | folD | STRIC_1217 | STRIC_0408 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.964 |
| EHI69449.1 | glyA | STRIC_1217 | STRIC_1300 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.966 |
| EHI69449.1 | lpdA | STRIC_1217 | STRIC_0989 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Dihydrolipoyl dehydrogenase. | 0.955 |
| EHI69449.1 | luxS | STRIC_1217 | STRIC_1674 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | S-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.971 |
| EHI69449.1 | metE | STRIC_1217 | STRIC_1216 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.999 |
| EHI69449.1 | metK | STRIC_1217 | STRIC_0510 | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.973 |
| EHI69502.1 | EHI69449.1 | STRIC_1153 | STRIC_1217 | Glycine cleavage H-protein. | Bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein. | 0.957 |
| EHI69502.1 | fhs_1 | STRIC_1153 | STRIC_1157 | Glycine cleavage H-protein. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.717 |
| EHI69502.1 | folD | STRIC_1153 | STRIC_0408 | Glycine cleavage H-protein. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.952 |
| EHI69502.1 | glyA | STRIC_1153 | STRIC_1300 | Glycine cleavage H-protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.963 |
