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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
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experimentally determined
co-expression
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gene co-occurrence
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pus10THUMP domain-containing protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (444 aa)    
Predicted Functional Partners:
srp54
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
       0.862
rpl21e
COGs: COG2139 Ribosomal protein L21E; InterPro IPR018259: IPR001147; KEGG: dka:DKAM_1408 50S ribosomal protein L21e; PFAM: Ribosomal protein L21e; SPTR: 50S ribosomal protein L21e; PFAM: Ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family.
 
     0.793
ADV65166.1
COGs: COG1867 N2 N2-dimethylguanosine tRNA methyltransferase; InterPro IPR002905; KEGG: dka:DKAM_0811 N2,N2-dimethylguanosine tRNA methyltransferase; PFAM: N2N2-dimethylguanosine tRNA methyltransferase; SPTR: N2,N2-dimethylguanosine tRNA methyltransferase; PFAM: N2,N2-dimethylguanosine tRNA methyltransferase; TIGRFAM: tRNA(guanine-26,N2-N2) methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
 
   
 0.775
ADV64357.1
Methyltransferase; COGs: COG2263 RNA methylase; InterPro IPR002052; KEGG: dka:DKAM_1413 predicted DNA methylase; SPTR: Predicted DNA methylase; PFAM: Putative RNA methylase family UPF0020.
 
     0.751
ADV65393.1
tRNA pseudouridine synthase D TruD; COGs: COG0585 conserved hypothetical protein; InterPro IPR001656: IPR011760; KEGG: dka:DKAM_1075 tRNA pseudouridine synthase D; PFAM: tRNA pseudouridine synthase D TruD; SPTR: tRNA pseudouridine synthase D; PFAM: tRNA pseudouridine synthase D (TruD); TIGRFAM: tRNA pseudouridine synthase, TruD family.
   
  
 0.697
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
     
 0.670
ADV64349.1
Ribosomal RNA adenine methylase transferase; COGs: COG0030 Dimethyladenosine transferase (rRNA methylation); InterPro IPR020598: IPR001737; KEGG: dka:DKAM_1405 probable dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase; SMART: Ribosomal RNA adenine methylase transferase-like; SPTR: Probable dimethyladenosine transferase; manually curated; PFAM: Ribosomal RNA adenine dimethylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
 
   
 0.666
ADV64351.1
RNA polymerase Rpb4; InterPro IPR006590: IPR005574; KEGG: dka:DKAM_1407 RNA polymerase Rpb4; PFAM: RNA polymerase Rpb4; SMART: RNA polymerase II, Rpb4, core; SPTR: RNA polymerase Rpb4; PFAM: RNA polymerase Rpb4.
       0.627
ADV64348.1
Methyltransferase small; COGs: COG2890 Methylase of polypeptide chain release factors; InterPro IPR002052: IPR007848; KEGG: dka:DKAM_1404 predicted rRNA or tRNA methylase; PFAM: methyltransferase small; SPTR: Predicted rRNA or tRNA methylase; PFAM: Methyltransferase small domain; TIGRFAM: HemK-related putative methylase.
 
     0.620
nop10
RNA-binding protein Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.
     
 0.600
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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