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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pus10THUMP domain-containing protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. (444 aa)    
Predicted Functional Partners:
srp54
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
       0.863
rpl21e
COGs: COG2139 Ribosomal protein L21E; InterPro IPR018259: IPR001147; KEGG: dka:DKAM_1408 50S ribosomal protein L21e; PFAM: Ribosomal protein L21e; SPTR: 50S ribosomal protein L21e; PFAM: Ribosomal protein L21e; Belongs to the eukaryotic ribosomal protein eL21 family.
 
   
 0.805
ADV64357.1
Methyltransferase; COGs: COG2263 RNA methylase; InterPro IPR002052; KEGG: dka:DKAM_1413 predicted DNA methylase; SPTR: Predicted DNA methylase; PFAM: Putative RNA methylase family UPF0020.
 
   
 0.751
ADV64349.1
Ribosomal RNA adenine methylase transferase; COGs: COG0030 Dimethyladenosine transferase (rRNA methylation); InterPro IPR020598: IPR001737; KEGG: dka:DKAM_1405 probable dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase; SMART: Ribosomal RNA adenine methylase transferase-like; SPTR: Probable dimethyladenosine transferase; manually curated; PFAM: Ribosomal RNA adenine dimethylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.
 
   
 0.719
ADV65166.1
COGs: COG1867 N2 N2-dimethylguanosine tRNA methyltransferase; InterPro IPR002905; KEGG: dka:DKAM_0811 N2,N2-dimethylguanosine tRNA methyltransferase; PFAM: N2N2-dimethylguanosine tRNA methyltransferase; SPTR: N2,N2-dimethylguanosine tRNA methyltransferase; PFAM: N2,N2-dimethylguanosine tRNA methyltransferase; TIGRFAM: tRNA(guanine-26,N2-N2) methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
 
   
 0.670
ADV64351.1
RNA polymerase Rpb4; InterPro IPR006590: IPR005574; KEGG: dka:DKAM_1407 RNA polymerase Rpb4; PFAM: RNA polymerase Rpb4; SMART: RNA polymerase II, Rpb4, core; SPTR: RNA polymerase Rpb4; PFAM: RNA polymerase Rpb4.
     
 0.632
ADV64348.1
Methyltransferase small; COGs: COG2890 Methylase of polypeptide chain release factors; InterPro IPR002052: IPR007848; KEGG: dka:DKAM_1404 predicted rRNA or tRNA methylase; PFAM: methyltransferase small; SPTR: Predicted rRNA or tRNA methylase; PFAM: Methyltransferase small domain; TIGRFAM: HemK-related putative methylase.
 
     0.591
ADV64350.1
Protein of unknown function DUF655; COGs: COG1491 RNA-binding protein; InterPro IPR007003; KEGG: dka:DKAM_1406 DNA-binding protein; PFAM: protein of unknown function DUF655; SPTR: DNA-binding protein; PFAM: Protein of unknown function, DUF655.
     
 0.581
ADV64515.1
Protein of unknown function DUF814; COGs: COG1293 RNA-binding protein homologous to eukaryotic snRNP; InterPro IPR008616: IPR008532; KEGG: dka:DKAM_0025 protein of unknown function DUF814; PFAM: protein of unknown function DUF814; Fibronectin-binding A domain protein; SPTR: Putative uncharacterized protein; PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA).
 
     0.528
ADV64347.1
tRNA/rRNA methyltransferase (SpoU); COGs: COG0565 rRNA methylase; InterPro IPR004384: IPR001537; KEGG: dka:DKAM_1403 SpoU rRNA methylase; PFAM: tRNA/rRNA methyltransferase (SpoU); SPTR: SpoU rRNA methylase; manually curated; PFAM: SpoU rRNA Methylase family; TIGRFAM: RNA methyltransferase, TrmH family, group 1.
       0.521
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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