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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
priSDNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (375 aa)    
Predicted Functional Partners:
priL
DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.
 
 0.999
pcn
Proliferating cell nuclear antigen PcnA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.983
ADV65577.1
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR006172: IPR006133: IPR006134: IPR017966: IPR 004578: IPR017964; KEGG: dka:DKAM_1295 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B; SPTR: DNA polymerase; TIGRFAM: DNA polymerase Pol2; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain; TIGRFAM: DNA polymerase (pol2).
   
 0.946
ADV65599.1
COGs: COG0417 DNA polymerase elongation subunit (family B); InterProIPR006172: IPR006133: IPR006134: IPR017966: IPR 017964; KEGG: dka:DKAM_1314 DNA polymerase I; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; SMART: DNA-directed DNA polymerase B; SPTR: DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.
  
 0.945
ADV64365.1
KEGG: dka:DKAM_1421 hypothetical protein; SPTR: Putative uncharacterized protein.
     
 0.901
ADV64887.1
Replicative DNA helicase Mcm; COGs: COG1241 ATPase involved in replication control Cdc46/Mcm family; InterPro IPR001208: IPR003593; KEGG: dka:DKAM_0687 MCM family protein; PFAM: MCM family protein; SMART: MCM family protein; AAA ATPase; SPTR: MCM family protein; PFAM: MCM2/3/5 family; Belongs to the MCM family.
  
 0.900
ADV64321.1
ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication.
 
 
 0.893
ADV64427.1
ORC complex protein Cdc6/Orc1; Involved in regulation of DNA replication.
 
 
 0.879
pcn-2
DNA polymerase sliding clamp subunit A; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.878
pcn-3
DNA polymerase sliding clamp subunit B; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 0.878
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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