close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
speHAdenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (122 aa)    
Predicted Functional Partners:
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
 
 
 0.996
ADV64514.1
COGs: COG1812 S-adenosylmethionine synthetase; InterPro IPR002795; KEGG: dka:DKAM_0024 S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase (MAT); PRIAM: Methionine adenosyltransferase; SPTR: S-adenosylmethionine synthetase; PFAM: S-adenosylmethionine synthetase (AdoMet synthetase).
  
  
 0.929
ADV65551.1
DNA-cytosine methyltransferase; COGs: COG0270 Site-specific DNA methylase; InterPro IPR001525; KEGG: dka:DKAM_1265 cytosine-specific DNA methylase; PFAM: C-5 cytosine-specific DNA methylase; SPTR: Cytosine-specific DNA methylase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase; TIGRFAM: DNA-methyltransferase (dcm); Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
  0.900
ADV64484.1
Monooxygenase FAD-binding protein; COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR003042: IPR002938; KEGG: dka:DKAM_0002 putative dehydrogenase (flavoprotein), FixC; PFAM: monooxygenase FAD-binding; SPTR: Putative dehydrogenase (Flavoprotein), FixC; PFAM: Lycopene cyclase protein.
       0.869
ADV64546.1
Agmatinase; COGs: COG0010 Arginase/agmatinase/formimionoglutamate hydrolase arginase family; InterPro IPR020855: IPR006035: IPR005925; KEGG: dka:DKAM_0053 agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; SPTR: Agmatinase; TIGRFAM: agmatinase; PFAM: Arginase family; TIGRFAM: agmatinase; Belongs to the arginase family.
     
 0.479
ADV65495.1
Translation initiation factor, aIF-2BI family; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.
     
 0.444
gap
COGs: COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; InterProIPR006436: IPR020830: IPR020831: IPR020828: IPR 020829; KEGG: dka:DKAM_0185 glyceraldehyde-3-phosphate dehydrogenase; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain; Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain; PRIAM: Glyceraldehyde-3-phosphate dehydrogenase (NAD(P)(+)) (phosphorylating); SPTR: Glyceraldehyde-3-phosphate dehydrogenase; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II; PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-termin [...]
  
  
 0.443
ADV64932.1
Class II aldolase/adducin family protein; COGs: COG0235 Ribulose-5-phosphate 4-epimerase and related epimerase and aldolase; InterPro IPR000169: IPR001303; KEGG: dka:DKAM_0314 class II aldolase/adducin family protein; PFAM: class II aldolase/adducin family protein; SPTR: Class II aldolase/adducin family protein; PFAM: Class II Aldolase and Adducin N-terminal domain; TIGRFAM: L-ribulose-5-phosphate 4-epimerase.
     
 0.411
ADV65214.1
Inositol monophosphatase; COGs: COG0483 fructose-1 6-bisphosphatase of inositol monophosphatase family; InterPro IPR020583: IPR000760; KEGG: dka:DKAM_0914 inositol-1-monophosphatase; PFAM: inositol monophosphatase; SPTR: Inositol-1-monophosphatase; PFAM: Inositol monophosphatase family.
  
  
 0.402
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.