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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV64490.1InterPro IPR000644; KEGG: dka:DKAM_1471 CBS domain containing protein; PFAM: CBS domain containing protein; SPTR: CBS domain containing protein; PFAM: CBS domain. (275 aa)    
Predicted Functional Partners:
ADV64489.1
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644; KEGG: dka:DKAM_1472 putative signal transduction protein with CBS domain; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: Putative signal transduction protein with CBS domain; PFAM: CBS domain.
 
     0.902
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
 
 0.890
ADV64491.1
Protein of unknown function DUF82; COGs: COG1656 conserved hypothetical protein; InterPro IPR002782; KEGG: dka:DKAM_1470 protein of unknown function DUF82; PFAM: protein of unknown function DUF82; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function DUF82.
       0.876
ADV64492.1
AMMECR1 domain protein; COGs: COG2078 conserved hypothetical protein; InterPro IPR002733; KEGG: dka:DKAM_1469 AMMECR1 domain protein; PFAM: AMMECR1 domain protein; SPTR: AMMECR1 domain protein; PFAM: AMMECR1; TIGRFAM: uncharacterized protein, PH0010 family.
  
    0.865
ADV64984.1
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027: IPR004099: IPR000815; KEGG: dka:DKAM_0296 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.
  
 
 0.651
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
   
 
 0.632
nadE
NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
    0.621
ADV64488.1
Sulfide dehydrogenase (flavoprotein) subunit SudB; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterProIPR017927: IPR012165: IPR008333: IPR001433: IPR 019480; KEGG: kcr:Kcr_0345 ferredoxin-NADP(+) reductase subunit alpha; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; SPTR: Oxidoreductase FAD/NAD(P)-binding domain protein; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of di [...]
  
 
 0.583
ADV64900.1
Protein of unknown function ATP binding protein; COGs: COG1100 GTPase SAR1 and related small G protein; InterPro IPR004130; KEGG: dka:DKAM_0542 GTPase; PFAM: protein of unknown function ATP binding; SPTR: Predicted ATP binding protein; PFAM: Conserved hypothetical ATP binding protein.
  
 0.574
ADV64970.1
Protein of unknown function ATP binding protein; COGs: COG1100 GTPase SAR1 and related small G protein; InterPro IPR004130; KEGG: dka:DKAM_0278 GTPase; PFAM: protein of unknown function ATP binding; SPTR: Putative uncharacterized protein; PFAM: Conserved hypothetical ATP binding protein.
  
 0.574
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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