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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADV64538.1COGs: COG2872 metal-dependent hydrolase related to alanyl-tRNA synthetase HxxxH domain; InterPro IPR018165: IPR018164: IPR012947; KEGG: dka:DKAM_0059 threonyl/alanyl tRNA synthetase; PFAM: Threonyl/alanyl tRNA synthetase SAD; Alanyl-tRNA synthetase, class IIc-like; SPTR: Threonyl/alanyl tRNA synthetase; PFAM: Threonyl and Alanyl tRNA synthetase second additional domain; tRNA synthetases class II (A). (238 aa)    
Predicted Functional Partners:
ADV64824.1
COGs: COG0495 Leucyl-tRNA synthetase; InterProIPR001412: IPR004493: IPR015413: IPR020754: IPR 013155; KEGG: dka:DKAM_0624 leucyl-tRNA synthetase; PFAM: tRNA synthetase valyl/leucyl anticodon-binding; tRNA synthetase class I (M); Lysyl-tRNA synthetase, class Ic; SPTR: Leucyl-tRNA synthetase; TIGRFAM: leucyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain; TIGRFAM: leucyl-tRNA synthetase, archaeal and cytosolic family; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.786
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 
 0.777
ADV65367.1
COGs: COG0525 Valyl-tRNA synthetase; InterPro IPR019754: IPR002300: IPR013155: IPR004039; KEGG: dka:DKAM_1053 valyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ia; tRNA synthetase valyl/leucyl anticodon-binding; SPTR: Valyl-tRNA synthetase; PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain.
  
  
 0.744
ADV64876.1
COGs: COG0519 GMP synthase PP-ATPase domain/subunit; InterProIPR017926: IPR006220: IPR011702: IPR004739: IPR 001674: IPR000991; KEGG: dka:DKAM_0479 GMP synthase; PFAM: GMP synthase domain protein; glutamine amidotransferase class-I; SPTR: GMP synthase; TIGRFAM: GMP synthase, large subunit; GMP synthase, small subunit; PFAM: GMP synthase C terminal domain; Glutamine amidotransferase class-I; NAD synthase; TIGRFAM: GMP synthase (glutamine-hydrolyzing), C-terminal domain or B subunit; GMP synthase (glutamine-hydrolyzing), N-terminal domain or A subunit.
  
  
 0.733
hisS
COGs: COG0124 Histidyl-tRNA synthetase; InterProIPR015807: IPR004516: IPR002314: IPR004154: IPR 006195; KEGG: dka:DKAM_1211 histidyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; PRIAM: Histidine--tRNA ligase; SPTR: Histidyl-tRNA synthetase; TIGRFAM: histidyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.719
thrS
COGs: COG0441 Threonyl-tRNA synthetase; InterProIPR018158: IPR002320: IPR015011: IPR002314: IPR 004154: IPR006195; KEGG: dka:DKAM_1216 threonyl-tRNA synthetase; PFAM: Threonyl-tRNA synthetase editing domain-containing protein; tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; SPTR: Threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); Archaea-specific editing domain of threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA [...]
  
 
 0.714
ADV64547.1
COGs: COG0423 Glycyl-tRNA synthetase (class II); InterPro IPR006195: IPR002315: IPR002314: IPR004154; KEGG: dka:DKAM_0052 glycyl-tRNA synthetase; PFAM: tRNA synthetase class II (G H P and S); Anticodon-binding domain protein; SPTR: Glycyl-tRNA synthetase; TIGRFAM: glycyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: glycyl-tRNA synthetase, dimeric type.
  
 
 0.668
ADV65210.1
COGs: COG0075 Serine-pyruvate aminotransferase/ aspartate aminotransferase; InterPro IPR020578: IPR000192; KEGG: dka:DKAM_0918 aspartate/serine transaminase; PFAM: aminotransferase class V; SPTR: Aspartate/serine transaminase; PFAM: Aminotransferase class-V.
  
  
 0.662
htpX
Heat shock protein; COGs: COG0501 Zn-dependent protease with chaperone function; InterPro IPR001915; KEGG: dka:DKAM_0358 probable protease HtpX - like protein; PFAM: peptidase M48 Ste24p; SPTR: Probable protease htpX-like protein; PFAM: Peptidase family M48; Belongs to the peptidase M48B family.
  
    0.661
ADV64905.1
COGs: COG0143 Methionyl-tRNA synthetase; InterPro IPR014758: IPR001412: IPR002304: IPR015413; KEGG: dka:DKAM_0547 methionyl-tRNA synthetase; PFAM: tRNA synthetase class I (M); SPTR: Methionyl-tRNA synthetase; TIGRFAM: methionyl-tRNA synthetase; PFAM: Anticodon-binding domain; tRNA synthetases class I (M); TIGRFAM: methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.658
Your Current Organism:
Desulfurococcus mucosus
NCBI taxonomy Id: 765177
Other names: D. mucosus DSM 2162, Desulfurococcus mucosus DSM 2162, Desulfurococcus mucosus JCM 9187, Desulfurococcus mucosus str. DSM 2162, Desulfurococcus mucosus strain DSM 2162
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